Rabbit Polyclonal PIP5KL1(N-term) Antibody

The PIP5KL1 (N-term) antibody is designed to target the N-terminal region of Phosphatidylinositol-4-Phosphate 5-Kinase Like 1 (PIP5KL1), a protein implicated in phosphoinositide metabolism. PIP5KL1 belongs to the phosphatidylinositol-4-phosphate 5-kinase (PIP5K) family, which catalyzes the phosphorylation of phosphatidylinositol-4-phosphate (PI4P) to generate phosphatidylinositol-4.5-bisphosphate (PI4.5P2), a critical lipid secondary messenger regulating membrane trafficking, cytoskeleton dynamics, and cell signaling. Although less characterized than other PIP5K isoforms, PIP5KL1 is suggested to play roles in cellular processes such as vesicle transport and receptor signaling. The N-terminal region of PIP5KL1 may contain functional domains essential for its enzymatic activity or protein-protein interactions. This antibody is commonly used in techniques like Western blotting, immunofluorescence, or immunoprecipitation to study PIP5KL1 expression, localization, and interactions in various biological contexts. Researchers employ it to explore PIP5KL1's involvement in diseases linked to phosphoinositide dysregulation, including cancer, neurological disorders, and metabolic syndromes. Its specificity for the N-terminal epitope helps distinguish PIP5KL1 from homologous isoforms, aiding in isoform-specific functional studies. Validation data, such as knockout controls or peptide blocking, are critical to confirm antibody specificity.