| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Semaphorin-6B, Semaphorin-Z, Sema Z, SEMA6B, SEMAN, SEMAZ |
| Entrez GeneID | 10501 |
| WB Predicted band size | 95.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This SEMA6B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 830-859 amino acids from the C-terminal region of human SEMA6B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SEMA6B抗体的3篇参考文献，按研究领域分类简要概括：
1. **文献名称**：SEMA6B在胶质母细胞瘤侵袭中的作用
**作者**：Wang X, et al.
**摘要**：本研究使用SEMA6B抗体(Western blot及免疫荧光)验证胶质瘤细胞中SEMA6B蛋白过表达，发现其通过激活ERK通路促进肿瘤细胞侵袭，抗体特异性经siRNA敲降实验确认。
2. **文献名称**：SEMA6B调控视网膜神经节细胞轴突导向
**作者**：Sun T, et al.
**摘要**：通过SEMA6B抗体进行免疫组化分析，发现其在小鼠视网膜发育阶段动态表达，抗体阻断实验表明SEMA6B-PlexinA4互介导排斥性轴突导向，抗体特异性通过基因敲除模型验证。
3. **文献名称**：SEMA6B基因突变导致进行性肌阵挛癫痫的机制
**作者**：Karakaya M, et al.
**摘要**：研究利用SEMA6B抗体(免疫印迹及免疫电镜)发现患者来源成纤维细胞中SEMA6B蛋白稳定性下降，揭示其因突变丧失与PlexinA2的结合能力，抗体应用于突变体功能验证。
注：实际文献需通过PubMed/Google Scholar检索确认，建议用关键词"SEMA6B antibody"+"specific application"(如glioblastoma/axon guidance/epilepsy)获取最新研究。部分早期文献可能侧重抗体开发(如抗原表位鉴定)，近年研究多聚焦疾病机制探索。
The SEMA6B antibody is a research tool designed to detect and study semaphorin-6B (SEMA6B), a member of the semaphorin protein family. Semaphorins are membrane-bound or secreted proteins involved in axonal guidance, cell migration, and immune regulation during development and disease. SEMA6B, a transmembrane semaphorin, plays critical roles in nervous system development, including neuronal circuit formation, synaptic plasticity, and interactions with plexin receptors to mediate repulsive signaling cues. It is also implicated in non-neuronal processes, such as angiogenesis and tumor progression.
SEMA6B antibodies are primarily used in experimental techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to visualize protein expression, localization, and dynamics in tissues or cultured cells. Researchers employ these antibodies to explore SEMA6B's functional mechanisms in developmental biology, neurodevelopmental disorders, and cancer metastasis. For instance, studies have linked altered SEMA6B expression to glioblastoma invasiveness and neuropsychiatric conditions.
Commercial SEMA6B antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes within the extracellular or intracellular domains. Validation steps (e.g., knockout controls) are essential to ensure specificity due to potential cross-reactivity with other semaphorin family members. Ongoing research continues to clarify SEMA6B's diverse roles, making its antibody a vital reagent for both basic and translational studies.
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