| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2, CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2, Renal carcinoma antigen NY-REN-20, U2(RNU2) small nuclear RNA auxiliary factor 1-like 2, U2AF35-related protein, URP, ZRSR2, U2AF1-RS2, U2AF1L2, U2AF1RS2, URP |
| Entrez GeneID | 8233 |
| WB Predicted band size | 58.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This ZRSR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453-482 amino acids from the C-terminal region of human ZRSR2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于ZRSR2抗体的示例参考文献(内容为虚构示例，仅作格式参考)：
1. **"ZRSR2 mutations impair hematopoietic stem cell function in myelodysplastic syndromes"**
*作者：Kim Y et al. (2017)*
摘要：本研究利用特异性ZRSR2抗体，通过Western blot和免疫荧光技术，证实ZRSR2突变导致其蛋白表达缺失，进而影响RNA剪接和造血干细胞分化，为骨髓增生异常综合征(MDS)的机制提供新见解。
2. **"ZRSR2 antibody validation in splicing regulation analysis"**
*作者：Madan V et al. (2018)*
摘要：文章报道了一种高特异性ZRSR2单克隆抗体的开发，并应用于免疫沉淀(IP)实验，揭示ZRSR2与U2 snRNP复合物的相互作用，证明其在次要剪接体通路中的关键作用。
3. **"Loss of ZRSR2 promotes leukemogenesis via aberrant mRNA splicing"**
*作者：Shirai CL et al. (2020)*
摘要：通过ZRSR2抗体进行组织芯片(TMA)染色，发现ZRSR2蛋白在急性髓系白血病(AML)中低表达，其缺失导致致癌性剪接变异体积累，驱动白血病发生。
(注：以上文献为模拟示例，实际文献需通过PubMed/Google Scholar等平台以关键词“ZRSR2 antibody”或“ZRSR2 immunohistochemistry”检索。)
The ZRSR2 antibody is a tool used to detect the ZRSR2 protein, a component of the minor spliceosome involved in RNA splicing. ZRSR2 (Zinc Finger CCCH-Type, RNA Binding Motif and Serine/Arginine Rich 2) plays a role in recognizing and processing U12-type introns, a rare class of introns critical for proper gene expression. Mutations in the ZRSR2 gene, located on the X chromosome, are linked to myelodysplastic syndromes (MDS) and other myeloid neoplasms. These mutations often result in aberrant RNA splicing, contributing to cellular dysregulation and disease progression. As ZRSR2 is X-linked, males are more susceptible to loss-of-function mutations, which may explain the male predominance in certain MDS subtypes.
The ZRSR2 antibody is primarily utilized in research to study spliceosome mechanics, disease mechanisms, and genotype-phenotype correlations in hematologic malignancies. It enables detection of ZRSR2 expression levels, subcellular localization, and mutant isoforms via techniques like Western blotting, immunohistochemistry, or immunofluorescence. Recent studies highlight its utility in exploring clonal heterogeneity and therapeutic vulnerabilities in splicing factor-mutated cancers. However, commercial availability and validation data remain limited compared to antibodies targeting more common splicing factors like SF3B1 or SRSF2. Ongoing research aims to clarify ZRSR2's precise role in RNA processing and its potential as a biomarker or therapeutic target in precision oncology.
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