Rabbit Polyclonal GFI1B Antibody

The GFI1B antibody is a crucial tool for studying the role of Growth Factor Independence 1B (GFI1B), a zinc finger-containing transcriptional repressor pivotal in hematopoiesis. GFI1B, alongside its homolog GFI1. regulates the development and differentiation of hematopoietic lineages, particularly erythrocytes, megakaryocytes, and platelets. It functions by recruiting chromatin-modifying complexes to repress target genes, ensuring proper cell maturation and function. Dysregulation of GFI1B is linked to hematologic disorders, including thrombocytopenia, myelodysplastic syndromes, and leukemia. The GFI1B antibody enables researchers to detect and quantify GFI1B protein expression in cells and tissues, facilitating investigations into its mechanistic roles in normal and malignant hematopoiesis. It is widely used in techniques like Western blotting, immunofluorescence, and flow cytometry. Additionally, clinical studies utilize this antibody to explore GFI1B mutations associated with inherited bleeding disorders, aiding in diagnostics and therapeutic development. As GFI1B’s interplay with epigenetic regulators gains attention, the antibody also supports research into epigenetic therapies targeting blood cancers. Validated for specificity and sensitivity, GFI1B antibodies remain indispensable for unraveling its dual roles as a transcriptional gatekeeper and disease mediator in hematologic systems.