Rabbit Polyclonal Phospho-TSC1(S511) Antibody

Phospho-TSC1(S511) antibody is designed to detect the phosphorylation of tuberous sclerosis complex 1 (TSC1) at serine residue 511. a post-translational modification implicated in regulating the TSC1-TSC2 complex activity. The TSC1-TSC2 complex acts as a critical suppressor of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway, which integrates cellular responses to growth factors, energy status, and nutrient availability. Phosphorylation of TSC1 at S511 has been linked to the modulation of mTORC1 activity, though its precise regulatory role remains under investigation. Studies suggest this phosphorylation event may be mediated by kinases such as IκB kinase β (IKKβ) in response to pro-inflammatory signals or other stress conditions, potentially destabilizing the TSC1-TSC2 complex or altering its subcellular localization. This can lead to mTORC1 activation, promoting cell growth, protein synthesis, and inhibition of autophagy. Researchers utilize Phospho-TSC1(S511) antibodies in techniques like Western blotting, immunoprecipitation, or immunofluorescence to study mTOR pathway dysregulation in diseases such as cancer, metabolic disorders, and neurological conditions like tuberous sclerosis. The antibody’s specificity for the phosphorylated form of TSC1 helps elucidate context-dependent signaling mechanisms and therapeutic targets in mTOR-related pathologies.