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Rabbit Polyclonal Phospho-KIT(S891) Antibody

  • 中文名： Phospho-KIT(S891)抗体
  • 别    名： Mast/stem cell growth factor receptor Kit, SCFR, Piebald trait protein, PBT, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit, p145 c-kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, CD117, KIT, SCFR
货号: IPDX32420
Price： ￥1280
数量：
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验证与应用

应用及物种
WB DB: 1/500 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesMast/stem cell growth factor receptor Kit, SCFR, Piebald trait protein, PBT, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit, p145 c-kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, CD117, KIT, SCFR
Entrez GeneID3815
WB Predicted band size109.9kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis KIT Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S891 of human KIT.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于 **Phospho-KIT(S891) 抗体** 的参考文献示例(内容为虚构，仅供参考，实际文献需通过学术数据库查询)：

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1. **文献名称**: *"Phosphorylation of KIT at Serine 891 Regulates Mast Cell Differentiation and Survival"*

**作者**: Zhang Y, et al.

**摘要**: 本研究揭示了KIT受体酪氨酸激酶在S891位点的磷酸化对肥大细胞分化和存活的关键作用。通过Phospho-KIT(S891)抗体的Western blot分析，发现该位点的磷酸化受SCF(干细胞因子)激活，并参与下游PI3K/AKT信号通路的调控。

2. **文献名称**: *"Role of KIT-S891 Phosphorylation in Gastrointestinal Stromal Tumor (GIST) Drug Resistance"*

**作者**: Tanaka H, et al.

**摘要**: 文章探讨了KIT-S891磷酸化在伊马替尼(Imatinib)耐药GIST细胞中的作用。使用Phospho-KIT(S891)抗体进行免疫沉淀实验，证明耐药细胞中该位点的持续磷酸化与异常激活的MAPK通路相关，提示其作为潜在治疗靶点。

3. **文献名称**: *"A Novel Phospho-Specific Antibody for KIT-S891 Reveals Dynamic Phosphorylation in Hematopoietic Stem Cells"*

**作者**: Müller R, et al.

**摘要**: 研究团队开发了一种高特异性的Phospho-KIT(S891)抗体，并验证其在流式细胞术和免疫组化中的应用。实验表明，S891磷酸化在造血干细胞增殖和归巢过程中具有动态调控功能。

4. **文献名称**: *"SCF-Induced KIT Phosphorylation at Serine 891 Modulates Melanocyte Migration"*

**作者**: Lee S, et al.

**摘要**: 通过Phospho-KIT(S891)抗体的功能研究，发现黑色素细胞迁移依赖于SCF激活的KIT-S891磷酸化，该过程通过Rho GTPase信号通路介导，为色素沉着疾病机制提供了新见解。

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**注**：以上文献为示例，实际引用时请通过 **PubMed、Web of Science** 或 **Google Scholar** 查询真实文献，并核对抗体应用的具体细节。

背景信息

Phospho-KIT(S891) antibody is a specialized tool used to detect the activated form of the KIT receptor tyrosine kinase at serine residue 891. KIT (CD117) is a transmembrane protein critical for cell signaling pathways regulating proliferation, survival, and differentiation. It is expressed in hematopoietic stem cells, mast cells, and interstitial cells of Cajal. Dysregulated KIT signaling, often due to gain-of-function mutations, is implicated in cancers like gastrointestinal stromal tumors (GISTs) and systemic mastocytosis. Phosphorylation at specific residues, including S891. modulates KIT activity and downstream signaling. While most studies focus on tyrosine phosphorylation (e.g., Y703. Y719), serine phosphorylation sites like S891 may play roles in feedback regulation or interaction with adaptor proteins. The S891 site is thought to be phosphorylated by protein kinase C (PKC) or other serine/threonine kinases, potentially influencing receptor internalization, degradation, or crosstalk with other pathways. Phospho-KIT(S891) antibody is utilized in research to investigate KIT activation dynamics, particularly in contexts of drug resistance or atypical signaling mechanisms. Its applications include Western blotting, immunohistochemistry, and functional studies to elucidate how post-translational modifications fine-tune KIT-driven oncogenesis or hematopoiesis. Understanding S891 phosphorylation could aid in developing targeted therapies for KIT-associated malignancies.

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