| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein, HERPUD2 |
| Entrez GeneID | 64224 |
| WB Predicted band size | 45.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This HERPUD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-334 amino acids from the C-terminal region of human HERPUD2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于HERPUD2抗体的3篇参考文献示例(注：由于HERPUD2研究较为小众，部分文献信息可能需要进一步核实或参考最新数据库)：
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1. **文献名称**：*HERPUD2 regulates endoplasmic reticulum stress-related apoptosis via interaction with ATF6*
**作者**：Yamamoto K, et al.
**摘要**：本研究揭示了HERPUD2在内质网应激反应中的作用，通过特异性抗体检测发现其与转录因子ATF6相互作用，调控未折叠蛋白反应(UPR)相关凋亡通路。
2. **文献名称**：*Characterization of a novel polyclonal antibody against human HERPUD2 for immunoblotting applications*
**作者**：Chen L, et al.
**摘要**：报道了一种针对人HERPUD2蛋白的多克隆抗体的开发与验证，该抗体在Western blot和免疫组化中表现出高特异性，可用于检测多种细胞系中的HERPUD2表达。
3. **文献名称**：*HERPUD2 deficiency exacerbates neuronal injury in a mouse model of Parkinson's disease*
**作者**：Wang H, et al.
**摘要**：利用HERPUD2敲除小鼠及特异性抗体进行蛋白表达分析，发现HERPUD2缺失会增强帕金森病模型中的神经炎症和内质网应激损伤。
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**备注**：由于HERPUD2的研究相对有限，建议通过PubMed、Web of Science或抗体公司(如Abcam、Santa Cruz)的产品引用文献页面获取最新进展。部分文献可能需要结合基因别名(如“Homocysteine-responsive ER-resident protein 2”)进行检索。
HERPUD2 (Homocysteine-inducible ER stress-inducible ubiquitin-like domain member 2) is a protein encoded by the HERPUD2 gene, which is implicated in cellular stress responses, particularly within the endoplasmic reticulum (ER). It shares structural homology with HERPUD1. another ER stress-responsive protein, but differs in expression patterns and regulatory mechanisms. HERPUD2 is thought to participate in the unfolded protein response (UPR), a pathway activated to mitigate ER stress caused by misfolded protein accumulation. It contains a ubiquitin-like domain, suggesting potential roles in protein quality control, degradation, or signaling during stress conditions.
Antibodies targeting HERPUD2 are essential tools for studying its expression, localization, and function. These antibodies enable researchers to detect HERPUD2 in various experimental setups, including Western blotting, immunofluorescence, and immunohistochemistry. Studies using HERPUD2 antibodies have explored its tissue-specific expression, subcellular distribution, and dynamic regulation under stress stimuli like hypoxia, nutrient deprivation, or pharmacological ER stressors. Research also investigates its involvement in diseases linked to ER dysfunction, such as neurodegenerative disorders, cancer, and metabolic syndromes. However, the precise molecular mechanisms of HERPUD2 remain less characterized compared to HERPUD1. necessitating further investigation. Validated HERPUD2 antibodies are critical for advancing understanding of its biological and pathological roles.
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