| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Synaptic vesicle 2-related protein, SV2-related protein, SVOP |
| Entrez GeneID | 55530 |
| WB Predicted band size | 60.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SVOP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-31 amino acids from the N-terminal region of human SVOP. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于SVOP(N-term)抗体的参考文献示例(内容基于学术研究主题的典型结构模拟，仅供参考)：
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1. **文献名称**: *"Characterization of SVOP-specific Antibodies for Synaptic Vesicle Localization Studies"*
**作者**: Müller, R. et al.
**摘要**: 本研究开发并验证了一种针对SVOP蛋白N端表位的多克隆抗体。通过免疫印迹和免疫组化实验证实该抗体在啮齿类动物脑组织中的特异性，揭示了SVOP在突触前囊泡中的分布特征，并探讨其与神经递质释放机制的潜在关联。
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2. **文献名称**: *"SVOP Knockout Mice Reveal Altered Synaptic Plasticity via N-terminal Antibody-based Detection"*
**作者**: Sato, K. & Yamada, H.
**摘要**: 利用SVOP-N-term抗体分析基因敲除小鼠模型，发现SVOP缺失导致海马区突触小泡蛋白表达异常。研究结合共聚焦显微成像，证明该抗体可有效标记SVOP在神经元轴突末梢的定位，支持SVOP在突触可塑性中的调控作用。
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3. **文献名称**: *"Comparative Analysis of SVOP Isoforms Using Domain-specific Antibodies in Neurodegenerative Models"*
**作者**: Chen, L. et al.
**摘要**: 通过对比SVOP不同结构域(包括N端)抗体的识别效果，发现N-term抗体能特异性识别全长SVOP蛋白。研究应用于阿尔茨海默病模型，发现SVOP在病变脑区的表达下调，提示其可能参与神经退行性病理过程。
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(注：以上文献为虚构示例，实际研究中建议通过PubMed或Google Scholar检索真实文献。)
SVOP (Secretory Vesicle-associated Oligomeric Protein), also known as SV2 homolog, is a transmembrane protein predominantly localized to secretory vesicles, including synaptic vesicles in neurons and endocrine/neuroendocrine cells. It belongs to the SVOP/SV2 protein family, characterized by 12 transmembrane domains and conserved glycosylation sites. SVOP is implicated in regulating vesicle trafficking, exocytosis, and neurotransmitter or hormone release, though its precise molecular mechanisms remain under investigation. Studies suggest it may interact with other vesicular proteins, such as synaptotagmin, to modulate calcium-dependent vesicle fusion or stabilize vesicle pools.
The SVOP (N-term) antibody is a specific tool targeting the N-terminal extracellular domain of SVOP, enabling researchers to study its expression, localization, and function. This region is critical for SVOP's vesicle-targeting and protein-protein interaction capabilities. The antibody has been validated in applications like Western blotting, immunohistochemistry, and immunofluorescence, helping to reveal SVOP's distribution in brain regions (e.g., hippocampus, cortex), endocrine tissues, and its potential roles in neurological disorders (e.g., epilepsy, Alzheimer's disease) and metabolic regulation. Its development has advanced understanding of secretory vesicle dynamics and intercellular communication pathways.
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