Rabbit Polyclonal COL9A3 Antibody

The COL9A3 antibody targets the alpha-3 chain of type IX collagen, a critical component of extracellular matrices in cartilage and other connective tissues. Type IX collagen, a heterotrimer formed by α1(IX), α2(IX), and α3(IX) chains encoded by COL9A1. COL9A2. and COL9A3 genes, respectively, interacts with type II collagen and plays a structural and regulatory role in tissue integrity. COL9A3 mutations are linked to skeletal disorders, including Stickler syndrome, multiple epiphyseal dysplasia (MED), and early-onset osteoarthritis, highlighting its importance in joint health. Antibodies against COL9A3 are essential tools for studying protein expression, localization, and dysfunction in disease models. They are widely used in immunohistochemistry, Western blotting, and immunofluorescence to investigate cartilage degeneration mechanisms or validate gene-editing outcomes. Research utilizing COL9A3 antibodies has advanced understanding of collagen IX’s role in maintaining cartilage resilience and its involvement in genetic or age-related musculoskeletal conditions. However, antibody specificity remains a consideration due to structural similarities among collagen family members. Ongoing studies aim to refine detection methods and explore therapeutic applications targeting COL9A3-associated pathways.