| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DEP domain-containing protein 7, Protein TR2/D15, DEPDC7 |
| Entrez GeneID | 91614 |
| WB Predicted band size | 58.13kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This DEPDC7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 439-467 amino acids from the C-terminal region of human DEPDC7. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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关于DEPDC7抗体的研究目前较为有限，以下是基于公开信息构造的示例性参考文献(仅供参考，建议通过PubMed或学术数据库核实最新研究)：
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1. **文献名称**: *DEPDC7 regulates cell proliferation via mTOR signaling pathway*
**作者**: Li X, et al.
**摘要**: 该研究利用DEPDC7抗体进行Western blot和免疫组化实验，发现DEPDC7通过抑制mTORC1通路调控细胞周期进程，提示其在癌症中的潜在作用。
2. **文献名称**: *Characterization of a novel polyclonal antibody against human DEPDC7 protein*
**作者**: Zhang Y, et al.
**摘要**: 文章报道了一种兔源多克隆抗体的开发与验证，通过免疫沉淀和免疫荧光证实该抗体可特异性识别内源性DEPDC7蛋白，适用于多种实验模型。
3. **文献名称**: *DEPDC7 interacts with Gβ subunits and modulates GPCR signaling*
**作者**: Wang H, et al.
**摘要**: 研究使用DEPDC7抗体进行共免疫沉淀实验，发现DEPDC7与G蛋白β亚基互作，可能参与G蛋白偶联受体(GPCR)信号通路的负调控。
4. **产品手册**: *Anti-DEPDC7 Antibody (Catalog No. ab123456)*
**厂商**: ABC Biotech
**摘要**: 商业抗体的技术文档，说明该抗体经ELISA和免疫印迹验证，推荐用于人、小鼠和大鼠组织的DEPDC7蛋白检测。
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**注意**：以上文献为示例性内容，实际研究中请通过学术数据库(如PubMed、Web of Science)或抗体供应商官网(如Thermo Fisher、Abcam)获取权威信息。DEPDC7的研究较少，建议结合相关通路(如mTOR、G蛋白信号)扩展检索。
The DEPDC7 antibody targets the DEP Domain-Containing Protein 7. a member of the DEP domain protein family implicated in regulating G protein-coupled receptor (GPCR) signaling and intracellular trafficking. DEP domains are conserved structural motifs involved in protein-protein interactions, membrane localization, and signal transduction. While the precise biological role of DEPDC7 remains poorly characterized, it is hypothesized to participate in cellular processes such as vesicle transport, cell polarity, or modulation of GPCR pathways, potentially influencing disease-relevant pathways.
DEPDC7 antibodies are primarily used as research tools to detect endogenous DEPDC7 expression in various experimental applications, including Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies enable the study of DEPDC7's tissue-specific distribution, subcellular localization, and expression levels under physiological or pathological conditions. Commercial DEPDC7 antibodies are typically raised in hosts like rabbits or mice, with validation across multiple species. However, due to limited functional studies, the antibody's utility is often coupled with exploratory research aiming to clarify DEPDC7's role in cellular mechanisms or diseases such as cancer or neurological disorders. Further investigation is required to define its interactors, signaling cascades, and therapeutic relevance.
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