Rabbit Polyclonal SF3A2 Antibody

The SF3A2 antibody targets the SF3A2 protein, a critical component of the spliceosome complex responsible for pre-mRNA splicing. SF3A2. part of the SF3a subcomplex (comprising SF3A1. SF3A2. and SF3A3), plays a vital role in recognizing branch site sequences during spliceosome assembly. This protein ensures accurate removal of introns and ligation of exons, a process essential for generating functional mRNA and regulating gene expression. Dysregulation of SF3A2 is linked to aberrant splicing events observed in cancers and genetic disorders. Antibodies against SF3A2 are widely used in research to study spliceosome dynamics, protein localization, and expression levels in various tissues or disease models. They facilitate techniques like Western blotting, immunofluorescence, and immunoprecipitation, aiding investigations into splicing mechanisms or therapeutic targets. SF3A2 is also explored as a potential biomarker in malignancies, as its overexpression correlates with tumor progression and drug resistance in some cancers. Studies using SF3A2 antibodies contribute to understanding the molecular basis of splicing-related pathologies and developing precision therapies targeting spliceosome vulnerabilities.