| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tau-tubulin kinase 1, Brain-derived tau kinase, TTBK1, BDTK, KIAA1855 |
| Entrez GeneID | 84630 |
| WB Predicted band size | 142.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TTBK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 667-695 amino acids from the Central region of human TTBK1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是模拟生成的关于TTBK1抗体的参考文献示例(注：以下内容为虚构，仅供格式参考，实际文献请通过学术数据库查询)：
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1. **文献名称**: *"Development of a Monoclonal Antibody Specific to TTBK1 and Its Application in Alzheimer's Disease Models"*
**作者**: Sato, K., et al. (2018)
**摘要**: 本研究开发了一种高特异性抗TTBK1单克隆抗体，用于检测阿尔茨海默病(AD)小鼠脑组织中的TTBK1表达。抗体通过Western blot和免疫组化验证，显示TTBK1在AD模型中的过度表达与tau蛋白异常磷酸化显著相关。
2. **文献名称**: *"TTBK1 Inhibition Reduces Tau Pathology: Insights from Antibody-Based Targeting in Neurodegeneration"*
**作者**: Tomizawa, Y., et al. (2020)
**摘要**: 通过新型抗TTBK1抗体干预实验，研究发现抑制TTBK1活性可降低tau蛋白的病理性磷酸化，改善转基因小鼠的认知功能障碍。抗体被用于体内外模型的靶向验证，支持TTBK1作为AD治疗潜在靶点。
3. **文献名称**: *"Characterization of TTBK1 Antibody for Neuronal Development Studies"*
**作者**: Gupta, R., & Lee, M. (2021)
**摘要**: 文章报道了一种兔源多克隆抗TTBK1抗体的开发，并用于分析小鼠胚胎神经元中的TTBK1时空表达模式。结果表明，TTBK1在轴突生长和突触形成中起关键作用，抗体特异性通过siRNA敲除实验证实。
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**建议**：实际研究中，可通过PubMed、Google Scholar等平台搜索关键词“TTBK1 antibody”、“TTBK1 tau kinase”或“TTBK1 neurodegeneration”获取最新文献。部分真实相关研究可能涉及TTBK1在tauopathy中的作用或抗体在诊断/机制研究中的应用。
TTBK1 (Tau Tubulin Kinase 1) is a serine/threonine kinase belonging to the casein kinase 1 (CK1) superfamily, initially identified for its ability to phosphorylate tau and tubulin proteins. It plays a critical role in regulating microtubule dynamics, neuronal development, and ciliogenesis. TTBK1 is highly expressed in the brain, particularly in neurons, where it modulates tau phosphorylation at specific sites linked to neurodegenerative diseases like Alzheimer’s. Dysregulation of TTBK1 has been implicated in tauopathies due to its contribution to abnormal tau aggregation, a hallmark of these disorders. Additionally, TTBK1 is essential for primary cilium formation, influencing signaling pathways such as Sonic Hedgehog (Shh).
Antibodies targeting TTBK1 are widely used in research to study its expression, localization, and functional interactions. They enable detection of TTBK1 in tissues or cultured cells via techniques like Western blot, immunohistochemistry, and immunofluorescence. Specific antibodies can distinguish between phosphorylated or isoform-specific forms of TTBK1. aiding in mechanistic studies of kinase activity or disease-related modifications. Commercial TTBK1 antibodies are typically raised in rabbits or mice, with validation in knockout models to ensure specificity. These tools are vital for exploring TTBK1's roles in neurodegeneration, ciliopathies, and potential therapeutic targeting.
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