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Rabbit Polyclonal MRPL45 Antibody

  • 中文名: MRPL45抗体
  • 别    名: 39S ribosomal protein L45, mitochondrial, L45mt, MRP-L45, MRPL45
货号: IPDX32335
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Aliases39S ribosomal protein L45, mitochondrial, L45mt, MRP-L45, MRPL45
WB Predicted band size35.4kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis MRPL45 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-245 amino acids from the C-terminal region of human MRPL45.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于MRPL45抗体的3篇参考文献示例(注:文献为虚拟生成,供参考):

1. **标题**: "MRPL45 regulates mitochondrial translation and apoptosis in cancer cells"

**作者**: Zhang Y, et al.

**摘要**: 研究通过Western blot和免疫组化技术,利用MRPL45抗体证明该蛋白在肺癌细胞中高表达,并调控线粒体翻译活性,抑制其表达可诱导细胞凋亡。

2. **标题**: "Mitochondrial ribosomal protein L45 modulates oxidative phosphorylation in cardiac hypertrophy"

**作者**: Lee S, et al.

**摘要**: 采用MRPL45抗体进行免疫沉淀和蛋白质组学分析,发现MRPL45与线粒体呼吸链复合物相互作用,其缺失导致心肌细胞能量代谢障碍,促进病理性心脏肥大。

3. **标题**: "A novel MRPL45 antibody-based assay for diagnosing mitochondrial disorders"

**作者**: Gupta R, et al.

**摘要**: 开发了一种高特异性MRPL45抗体,通过ELISA和免疫荧光技术检测患者样本,证实其在线粒体脑肌病诊断中的潜在临床应用价值。

提示:实际文献需通过PubMed或Google Scholar检索确认。部分商业抗体公司(如Abcam、Proteintech)的产品页面可能提供相关引用文献。

背景信息

The MRPL45 antibody is a research tool designed to detect the mitochondrial ribosomal protein L45 (MRPL45), a key component of the large subunit (39S) of the mitochondrial ribosome. MRPL45 plays a critical role in mitochondrial protein synthesis, which is essential for oxidative phosphorylation (OXPHOS) and cellular energy production. As part of the mitochondrial ribosome, it facilitates the assembly and stability of the ribosome structure, ensuring proper translation of mitochondrial DNA-encoded genes. Dysregulation of MRPL45 has been linked to mitochondrial dysfunction, contributing to diseases such as cancer, metabolic disorders, and neurodegenerative conditions. The MRPL45 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study protein expression, subcellular localization, and mitochondrial health in various models. Researchers also employ it to explore MRPL45's role in mitochondrial biogenesis, apoptosis, and stress responses. Validated for specificity in multiple species, this antibody aids in uncovering molecular mechanisms underlying mitochondrial diseases and potential therapeutic targets. Its application extends to diagnostics, where altered MRPL45 levels may serve as biomarkers for mitochondrial-related pathologies.

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