| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | [Protein ADP-ribosylarginine] hydrolase, ADP-ribosylarginine hydrolase, ADP-ribose-L-arginine cleaving enzyme, ADPRH, ARH1 |
| Entrez GeneID | 141 |
| WB Predicted band size | 39.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ADPRH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-334 amino acids from the C-terminal region of human ADPRH. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ADPRH抗体的3篇参考文献及其摘要概述：
1. **"Characterization of ADP-ribosylhydrolase (ADPRH) in DNA repair pathways"**
*Author: Smith J, et al.*
摘要：该研究通过开发特异性ADPRH抗体，揭示了ADPRH在DNA损伤修复中的功能，证实其通过水解ADP-核糖化修饰调控PARP1活性，影响细胞对辐射损伤的响应。
2. **"ADPRH expression and prognostic value in colorectal cancer"**
*Author: Lee S, et al.*
摘要：利用ADPRH抗体进行免疫组化分析，发现ADPRH在结直肠癌组织中表达下调，且低表达与患者生存率降低相关，提示其可能作为肿瘤抑制因子及潜在生物标志物。
3. **"Development of a monoclonal antibody targeting ADPRH for neurodegenerative disease research"**
*Author: Garcia R, et al.*
摘要：报道了一种高特异性ADPRH单克隆抗体的开发，验证了其在Western blot和免疫荧光中的适用性，并应用于阿尔茨海默病模型，发现ADPRH异常聚集与tau蛋白病理相关。
注：上述文献为虚拟示例，实际研究中建议通过PubMed或Google Scholar以关键词“ADPRH antibody”或“ADP-ribosylhydrolase antibody”检索最新实证论文。
The ADPRH antibody is a key reagent for investigating ADP-ribosylarginine hydrolase (ADPRH), an enzyme critical to the ADP-ribosylation cycle—a reversible post-translational modification involved in DNA repair, cell signaling, and apoptosis. ADPRH specifically hydrolyzes ADP-ribosylarginine bonds, reversing protein modifications mediated by ADP-ribosyltransferases (ARTs). This regulatory function helps maintain cellular homeostasis, with dysregulation linked to neurodegenerative disorders, cancer, and inflammatory diseases.
ADPRH antibodies enable the detection and quantification of ADPRH expression in tissues or cell lines via techniques like Western blotting, immunohistochemistry, and immunofluorescence. They are essential for studying ADPRH’s spatial-temporal localization, interaction partners, and role in disease mechanisms. For instance, researchers use these antibodies to explore ADPRH’s contribution to DNA damage responses or its potential as a therapeutic target.
High-quality ADPRH antibodies are typically raised in rabbits or mice against specific epitopes, validated for specificity through knockout controls or siRNA silencing. Commercial variants often include data on cross-reactivity and application suitability. By facilitating precise ADPRH analysis, these antibodies support advances in understanding ADP-ribosylation dynamics and their implications in pathology, offering insights for drug development and biomarker discovery.
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