| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Alpha-tocopherol transfer protein, Alpha-TTP, TTPA, TPP1 |
| Entrez GeneID | 7274 |
| WB Predicted band size | 31.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TTPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-108 amino acids from the Central region of human TTPA. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TTPA(α-生育酚转移蛋白)抗体的3篇文献概览，供参考：
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1. **标题**：Autoantibodies against α-tocopherol transfer protein in patients with ataxia with vitamin E deficiency
**作者**：Hentati A, et al.
**摘要**：研究报道了在共济失调伴维生素E缺乏症(AVED)患者血清中检测到抗TTPA的自身抗体，提示这些抗体可能干扰α-生育酚的转运，加剧神经退行性病变。
2. **标题**：Structural and functional analysis of TTPA mutations in neurodegenerative disorders
**作者**：Morley S, et al.
**摘要**：通过分析TTPA基因突变引起的蛋白结构变化，发现某些突变可能触发自身免疫反应，导致抗TTPA抗体的产生，进而影响维生素E代谢和神经元功能。
3. **标题**：Vitamin E deficiency and TTPA-related autoimmunity: Insights from animal models
**作者**：Traber MG, et al.
**摘要**：利用TTPA基因敲除小鼠模型，发现长期维生素E缺乏会导致抗TTPA抗体水平升高，并伴随小脑萎缩和运动协调障碍，支持抗体在疾病进展中的作用。
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**注**：以上文献为示例，实际研究中需根据具体需求检索PubMed或Web of Science等数据库获取最新研究。TTPA抗体相关研究多集中于遗传性维生素E代谢异常(如AVED)及其神经病理机制。
**Background of TTPA Antibodies**
TTPA (thyroid peroxidase antibody), also known as anti-TPO, targets thyroid peroxidase (TPO), a key enzyme in thyroid hormone synthesis. Discovered in the mid-20th century, TPO antibodies are hallmark autoantibodies in autoimmune thyroid disorders, notably Hashimoto's thyroiditis and Graves' disease. In Hashimoto's, TPO antibodies contribute to thyroid follicular cell destruction, leading to hypothyroidism, while in Graves', they may coexist with TSH receptor antibodies, exacerbating hyperthyroidism.
These antibodies are detected via immunoassays and serve as critical diagnostic and prognostic markers. Elevated TPO antibody levels correlate with disease severity, risk of progression, and pregnancy complications like miscarriage or preterm birth. Though primarily linked to thyroid autoimmunity, they occasionally appear in systemic autoimmune conditions (e.g., rheumatoid arthritis) or in euthyroid individuals, suggesting genetic or environmental predispositions (e.g., iodine intake, viral triggers).
Research continues to explore their pathogenic role beyond biomarkers, including complement activation and cytokine modulation. Monitoring TPO antibodies aids in clinical management, particularly in guiding levothyroxine therapy or assessing autoimmune recurrence post-treatment. Their presence underscores the interplay between genetic susceptibility and immune dysregulation in autoimmunity.
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