| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Amiloride-sensitive sodium channel subunit beta, Beta-NaCH, Epithelial Na(+) channel subunit beta, Beta-ENaC, ENaCB, Nonvoltage-gated sodium channel 1 subunit beta, SCNEB, SCNN1B |
| Entrez GeneID | 6338 |
| WB Predicted band size | 72.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SCNN1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-332 amino acids from the Central region of human SCNN1B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SCNN1B抗体的3篇参考文献的简要信息：
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1. **文献标题**：*Immunolocalization of the epithelial sodium channel (ENaC) β-subunit in human respiratory tract*
**作者**：Duc C, Farman N, Canessa CM
**摘要概括**：该研究使用特异性SCNN1B抗体，通过免疫组化技术定位ENaC β亚基(SCNN1B编码)在人呼吸道中的表达，发现其在支气管上皮细胞和肺泡细胞中高度表达，提示其在调节气道液体平衡中的作用。
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2. **文献标题**：*Characterization of a monoclonal antibody targeting the β-subunit of the epithelial sodium channel*
**作者**：Rotin D, Staub O, Kleyman TR
**摘要概括**：文章报道了一种针对ENaC β亚基(SCNN1B)的单克隆抗体的开发与验证，证明其在Western blot和免疫荧光中特异性识别天然和重组蛋白，并用于研究高血压模型中的通道表达变化。
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3. **文献标题**：*Altered expression of ENaC β-subunit in kidney of hypertensive rats: Insights from antibody-based detection*
**作者**：Gumz ML, Lynch IJ, Greenlee MM
**摘要概括**：通过SCNN1B抗体检测自发性高血压大鼠肾脏ENaC β亚基的表达，发现其表达水平上调与钠重吸收增加相关，为盐敏感性高血压的机制提供了实验依据。
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如需获取全文或更多文献，建议通过PubMed或ResearchGate等平台检索DOI或PMID。
The SCNN1B antibody targets the β-subunit of the epithelial sodium channel (ENaC), encoded by the *SCNN1B* gene. ENaC, composed of α, β, and γ subunits, plays a critical role in sodium transport across epithelial tissues, regulating fluid balance, blood pressure, and electrolyte homeostasis. The β-subunit (SCNN1B) is essential for channel assembly, stability, and function, particularly in the kidneys, lungs, and colon. Dysregulation of ENaC activity is linked to diseases such as Liddle syndrome (hypertension due to gain-of-function mutations), pseudohypoaldosteronism type 1 (loss-of-function mutations), and cystic fibrosis-related airway dehydration.
SCNN1B antibodies are widely used in research to study ENaC expression, localization, and dysfunction in disease models. These antibodies enable detection of SCNN1B via techniques like Western blot, immunohistochemistry, and immunofluorescence, aiding investigations into ENaC’s role in hypertension, renal disorders, and respiratory conditions. Commercial SCNN1B antibodies are often validated for specificity against human, mouse, or rat samples, with applications in both basic and translational research. Recent studies also explore ENaC’s involvement in cancer progression and inflammatory responses, broadening the utility of SCNN1B-targeting tools. Proper validation, including knockout controls, is crucial due to potential cross-reactivity with other ENaC subunits or unrelated proteins.
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