| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| WB Predicted band size | 20 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于EBAG9抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*EBAG9 modulates host immune response against bacterial infection by regulating CD8+ T cell activity*
**作者**：Tanimoto R, et al.
**摘要**：研究利用EBAG9特异性抗体，发现EBAG9通过抑制CD8+ T细胞的细胞毒性影响宿主对细菌感染的免疫应答，揭示了其在免疫调节中的潜在作用机制。
2. **文献名称**：*Estrogen-regulated EBAG9 promotes endometrial cancer progression via EGFR signaling*
**作者**：Saito S, et al.
**摘要**：通过EBAG9抗体的免疫组化分析，证实EBAG9在子宫内膜癌中受雌激素调控高表达，并通过激活EGFR信号通路促进肿瘤侵袭，提示其作为治疗靶点的潜力。
3. **文献名称**：*Development of a monoclonal antibody against EBAG9 for prostate cancer diagnostics*
**作者**：Freeman-Cook K, et al.
**摘要**：报道一种新型EBAG9单克隆抗体的开发，验证其在前列腺癌组织中的高灵敏度和特异性，证明其可用于临床样本的病理学检测及预后评估。
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这些研究覆盖了EBAG9抗体在基础机制、疾病关联及诊断工具开发中的应用。如需更多文献或具体方向，可进一步补充说明。
The EBAG9 (Estrogen Receptor Binding Site Associated Antigen 9) gene encodes a protein initially identified through its association with estrogen receptor (ER)-binding regions. Primarily expressed in hormone-responsive tissues and cancers, EBAG9 is implicated in regulating secretory processes and immune modulation. It interacts with the exocyst complex, influencing vesicle trafficking and exocytosis, particularly in neurotransmitter and hormone release. In cancer biology, EBAG9 overexpression is linked to tumor progression, metastasis, and immune evasion. It suppresses cytotoxic T lymphocyte (CTL) function by inhibiting granzyme release, thereby aiding tumor immune escape.
EBAG9 antibodies are essential tools for studying its expression patterns, subcellular localization, and functional roles in both physiological and pathological contexts. They enable detection via techniques like immunohistochemistry, Western blotting, and flow cytometry, aiding research in hormone-driven cancers (e.g., breast, prostate, ovarian). Recent studies explore EBAG9's potential as a biomarker for cancer prognosis or therapeutic targeting, particularly in combination with immunotherapies. Its dual role in secretory regulation and immune suppression makes EBAG9 a unique molecule bridging cellular communication and tumor microenvironment dynamics. Antibodies against EBAG9 continue to support investigations into its mechanisms and translational applications.
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