| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HTLF |
| WB Predicted band size | 47 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human FOXN2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ZNF773(N-term)抗体的3篇参考文献的简要概括(注：以下内容为示例性虚构，实际文献需通过数据库检索确认)：
1. **文献名称**：ZNF773 N-terminal antibody characterization in epigenetic regulation
**作者**：Smith A, et al.
**摘要**：该研究验证了ZNF773(N-term)抗体在染色质免疫沉淀(ChIP)中的特异性，证明其可用于检测ZNF773蛋白在启动子区域的结合，并发现其参与肿瘤抑制基因的表观遗传沉默。
2. **文献名称**：Role of ZNF773 in neuronal differentiation revealed by N-terminal specific antibody
**作者**：Chen L, et al.
**摘要**：通过Western blot和免疫荧光实验，利用ZNF773(N-term)抗体证实了该蛋白在神经干细胞分化中的表达动态变化，提示其可能调控神经发育相关通路。
3. **文献名称**：Development of a novel ZNF773 N-terminal monoclonal antibody for clinical diagnostics
**作者**：Wang Y, et al.
**摘要**：报道了一种高特异性ZNF773(N-term)单克隆抗体的开发，通过ELISA和免疫组化验证其在结直肠癌组织中的诊断潜力，显示与肿瘤分期相关的表达差异。
4. **文献名称**：ZNF773 interacts with KRAB-associated protein complex via its N-terminal domain
**作者**：Garcia R, et al.
**摘要**：利用ZNF773(N-term)抗体进行免疫共沉淀实验，揭示了其N端结构域与KAP1蛋白的相互作用，为锌指蛋白家族在染色质重塑中的功能机制提供新证据。
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注：以上内容为模拟生成，真实文献需通过PubMed、Google Scholar或抗体公司产品说明书(如Santa Cruz Biotechnology、Abcam等)提供的引用文献查询。建议通过关键词“ZNF773 antibody N-terminal”或“ZNF773 epitope mapping”在学术数据库中检索具体研究。
The ZNF773(N-term) antibody targets the N-terminal region of Zinc Finger Protein 773 (ZNF773), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein (ZNF) family. ZNF773 is a transcription factor implicated in gene regulation, particularly through epigenetic silencing via KRAB-ZFP interactions with repressive complexes like KAP1/TRIM28. These proteins play roles in chromatin remodeling, transposable element suppression, and cellular differentiation.
The N-terminal region of ZNF773 contains the KRAB domain, critical for protein-protein interactions and transcriptional repression. Antibodies specific to this domain are valuable tools for studying ZNF773’s localization, expression patterns, and molecular mechanisms in development or disease contexts. Research suggests ZNF773 may contribute to cancer progression, neurological disorders, or immune regulation, though its precise functions remain under investigation.
The ZNF773(N-term) antibody is commonly used in techniques such as Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to explore its DNA-binding properties or regulatory networks. Validation typically includes specificity tests in knockout models or siRNA-treated cells. Understanding ZNF773’s role through this antibody could advance insights into epigenetic regulation, cellular identity, and pathogenic pathways linked to ZNF dysregulation.
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