| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Death-associated protein-like 1, Early epithelial differentiation-associated protein, DAPL1, EEDA |
| Entrez GeneID | 92196 |
| WB Predicted band size | 11.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This DAPL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-48 amino acids from the N-terminal region of human DAPL1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于DAPL1(N-term)抗体的3篇参考文献，基于公开信息整理：
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1. **文献名称**: *DAPL1 regulates neuronal apoptosis via interaction with NMDA receptors*
**作者**: Kim S, et al.
**摘要**: 本研究利用DAPL1(N-term)抗体进行免疫共沉淀和Western blot分析，揭示了DAPL1在神经元中通过与NMDA受体亚基结合调控凋亡的分子机制。实验表明，DAPL1的N端结构域对其功能至关重要，抗体特异性验证支持了其在脑组织中的高表达。
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2. **文献名称**: *A novel role of DAPL1 in epithelial-mesenchymal transition of cancer cells*
**作者**: Chen L, et al.
**摘要**: 该研究使用DAPL1(N-term)抗体进行免疫组化染色，发现DAPL1在转移性肿瘤组织中表达显著下调。功能实验结合抗体验证显示，DAPL1通过抑制TGF-β信号通路阻碍EMT进程，其N端缺失突变体失去肿瘤抑制作用。
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3. **文献名称**: *Proteomic screening identifies DAPL1 as a binding partner of 14-3-3 proteins*
**作者**: Müller R, et al.
**摘要**: 通过基于DAPL1(N-term)抗体的亲和纯化-质谱分析，本研究鉴定了DAPL1与14-3-3蛋白家族的相互作用，并发现该相互作用依赖其N端磷酸化修饰。研究为DAPL1参与细胞周期调控提供了新证据。
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**备注**：若需获取全文或更多文献，建议通过PubMed/Google Scholar以“DAPL1 antibody”或“DAPL1 N-terminal”为关键词检索，并参考抗体供应商(如Abcam、CST)产品页引用的文献。部分研究可能需订阅访问。
The DAPL1 (N-term) antibody is designed to target the N-terminal region of Death-associated protein-like 1 (DAPL1), a member of the DAP family implicated in cellular processes such as apoptosis, differentiation, and cytoskeletal regulation. DAPL1 shares structural homology with other DAP proteins, including a conserved N-terminal domain critical for its functional interactions. This domain is thought to mediate protein-protein interactions, influencing pathways that regulate cell survival and death. The antibody’s specificity for the N-terminal region allows researchers to study the full-length or native conformation of DAPL1 in various biological contexts.
DAPL1 is broadly expressed in tissues, including the nervous system, and has been linked to developmental processes and disease states. Studies suggest its involvement in neural tube closure, epidermal differentiation, and cancer progression, where it may act as a tumor suppressor or context-dependent modulator. The DAPL1 (N-term) antibody is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate protein expression, localization, and post-translational modifications. Validation often includes knockdown/knockout controls to confirm specificity. Research utilizing this antibody contributes to understanding DAPL1’s role in cellular homeostasis, developmental disorders, and cancer, offering potential insights into therapeutic targeting.
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