关键信息
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基因名
CENPM
- 应用
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别名
CENPM；C22orf18；ICEN39；PANE1；Centromere Protein M
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NSP4
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表达区间
1-180aa
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氨基酸序列
MSVLRPLDKL PGLNTATILL VGTEDALLQQ LADSMLKEDC ASELKVHLAK SLPLPSSVNR PRIDLIVFVV NLHSKYSLQN TEESLRHVDA SFFLGKVCFL ATGAGRESHC SIHRHTVVKL AHTYQSPLLY CDLEVEGFRA TMAQRLVRVL QICAGHVPGV SALNLLSLLR SSEGPSLEDL
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
CENPM (Centromere Protein M) is a vital component of the centromere, which is essential for proper chromosome segregation during cell division. Recent studies have highlighted its role in the assembly and maintenance of the kinetochore, a crucial structure that facilitates the attachment of spindle fibers to chromosomes. Abnormalities in CENPM function or expression can lead to chromosomal instability, a hallmark of various cancers and genetic disorders. Understanding the molecular mechanisms underlying CENPM's role in the centromere and kinetochore dynamics is therefore critical for elucidating the processes of mitosis and meiosis. Researchers have focused on recombinant protein studies of CENPM to explore its structural and functional properties, aiming to uncover how it interacts with other centromeric proteins and DNA. These studies also involve the production of CENPM in heterologous expression systems, which allows for the purification and characterization of the protein. Insights gained from CENPM recombinant protein research not only shed light on its fundamental biological functions but also have potential implications for cancer therapy and the development of novel diagnostic tools to monitor chromosomal abnormalities in diseases. As such, the exploration of CENPM provides a promising avenue for advancing our understanding of chromosomal behavior and its relationship to human health.
