Rabbit Polyclonal MouseDyrk1a(C-term) Antibody

The Mouse Dyrk1a (C-term) antibody is designed to detect the C-terminal region of dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A), a serine/threonine/tyrosine kinase encoded by the *DYRK1A* gene. Dyrk1A plays critical roles in neurodevelopment, cell cycle regulation, and synaptic plasticity, with implications in Down syndrome, Alzheimer's disease, and cancer. Located on chromosome 21. its overexpression is linked to Down syndrome phenotypes. The C-terminal domain contributes to substrate recognition, protein-protein interactions, and regulatory functions. This antibody is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study endogenous Dyrk1A expression, localization, and molecular interactions in mouse tissues, particularly the brain. Specificity is validated through knockout controls or peptide blocking assays. Researchers employ it to explore Dyrk1A's role in neuronal differentiation, cognitive function, and disease mechanisms. The antibody typically recognizes the ~86 kDa protein and helps investigate post-translational modifications or truncations affecting kinase activity. Its applications extend to developmental biology and therapeutic target validation studies.