Rabbit Polyclonal MouseEphb6(Center) Antibody

The Ephb6 receptor, a member of the Eph receptor tyrosine kinase family, plays critical roles in cell-cell communication, tissue patterning, and developmental processes. Unlike many Eph receptors, Ephb6 lacks intrinsic kinase activity due to amino acid substitutions in its catalytic domain, yet it regulates signaling through interactions with other Eph receptors or downstream adaptors. It is implicated in cell adhesion, migration, and immune regulation, with emerging roles in cancer progression and metastasis. The Mouse Ephb6(Center) antibody is designed to target the central region of the Ephb6 protein, often used to detect endogenous levels of Ephb6 in mouse tissues or cell lines via techniques like Western blotting, immunohistochemistry, or immunofluorescence. This antibody is typically raised in rabbits or other hosts using a synthetic peptide or recombinant protein corresponding to the central domain of Ephb6. ensuring specificity for this region. Its application aids in studying Ephb6's functional mechanisms in neural development, immune responses, and tumor biology, particularly in models where Ephb6 expression or signaling is manipulated. Validation often includes knockout controls to confirm absence of cross-reactivity. Research utilizing this antibody contributes to understanding Ephb6's dual roles in both physiological homeostasis and disease contexts.