| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc fingers and homeoboxes protein 1, ZHX1 |
| Entrez GeneID | 11244 |
| WB Predicted band size | 98.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZHX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 771-800 amino acids from the C-terminal region of human ZHX1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZHX1(C-term)抗体的3篇参考文献示例(注：以下信息为模拟生成，实际文献需根据具体数据库检索验证)：
1. **文献名称**：*ZHX1 interacts with eIF4A2 to regulate liver cancer cell proliferation through translation control*
**作者**：Li, X., et al.
**摘要**：本研究利用ZHX1(C-term)抗体进行免疫共沉淀(Co-IP)实验，发现ZHX1通过C端结构域与翻译起始因子eIF4A2相互作用，调控肝癌细胞中特定致癌mRNA的翻译效率，从而影响肿瘤生长。
2. **文献名称**：*Tissue-specific expression and post-translational modification of ZHX1 revealed by a C-terminal specific antibody*
**作者**：Wang, Y., et al.
**摘要**：通过开发并验证一种针对ZHX1 C端表位的兔多克隆抗体，研究发现ZHX1在肾脏和肝脏组织中存在磷酸化修饰差异，提示其C端可能参与组织特异性功能调控。
3. **文献名称**：*ZHX1 forms a repressive complex with HDAC4 via its C-terminal domain to suppress neuronal differentiation genes*
**作者**：Chen, H., et al.
**摘要**：使用ZHX1(C-term)抗体的ChIP-seq分析显示，ZHX1通过C端与HDAC4结合形成转录抑制复合物，靶向神经元分化相关基因启动子，维持干细胞多能性。
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如需获取真实文献，建议在 **PubMed** 或 **Google Scholar** 中搜索关键词：`"ZHX1 C-terminal antibody"` 或 `"ZHX1 antibody" + "C-term"`，并筛选涉及该抗体应用的实验研究(如Western blot、IP等)。部分商业抗体公司(如Abcam、Proteintech)的产品手册也可能提供参考文献。
The ZHX1 (C-term) antibody is a specialized tool designed to detect the C-terminal region of Zinc Fingers and Homeoboxes Protein 1 (ZHX1), a member of the ZHX family (ZHX1. ZHX2. ZHX3). ZHX1 is a nuclear transcription repressor involved in regulating gene expression by binding to DNA or interacting with other transcription factors. It contains two zinc finger motifs and five homeodomains, with its C-terminal region playing a critical role in mediating protein-protein interactions, dimerization with other ZHX family members (e.g., ZHX2/ZHX3), and recruitment of transcriptional co-repressors. Dysregulation of ZHX1 has been linked to cancers, including hepatocellular carcinoma and breast cancer, where it may act as a tumor suppressor or oncogene depending on context.
The ZHX1 (C-term) antibody is widely used in research to study ZHX1’s expression, localization, and function via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its specificity for the C-terminal domain ensures detection of full-length ZHX1. avoiding cross-reactivity with truncated isoforms or degradation products. This antibody has been instrumental in elucidating ZHX1’s role in developmental processes, cell cycle regulation, and disease mechanisms, offering insights into its potential as a therapeutic target or diagnostic marker. Validation in knockout controls or peptide-blocking assays is recommended to confirm specificity.
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