Rabbit Polyclonal MouseCdk14(N-term) Antibody

The Mouse Cdk14 (N-term) antibody is a monoclonal or polyclonal antibody specifically designed to detect the N-terminal region of cyclin-dependent kinase 14 (Cdk14) in mouse-derived samples. Cdk14. a member of the CDK family, plays a role in cell cycle regulation, signal transduction, and developmental processes. Unlike canonical CDKs, CDK14 is classified as a "PCTAIRE" kinase due to its unique structural motifs, and it is implicated in Wnt/β-catenin signaling, influencing tissue development and carcinogenesis. The antibody is commonly used in techniques like Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF) to study CDK14 expression, localization, and interaction partners in murine models. Its specificity for the N-terminal domain ensures recognition of full-length or truncated isoforms, aiding in research on post-translational modifications or functional domains. Validation often includes testing in Cdk14 knockout tissues to confirm absence of cross-reactivity. Studies utilizing this antibody have explored CDK14's role in neural development, cancer progression, and cellular responses to signaling pathways. Researchers prioritize this tool for investigating cell cycle dysregulation in diseases or developmental disorders, leveraging its ability to provide insights into CDK14-mediated molecular mechanisms.