| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Paired mesoderm homeobox protein 1, Homeobox protein PHOX1, Paired-related homeobox protein 1, PRX-1, PRRX1, PMX1 |
| Entrez GeneID | 5396 |
| WB Predicted band size | 27.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PRRX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 213-242 amino acids from the C-terminal region of human PRRX1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及PRRX1(C-term)抗体的参考文献摘要信息：
1. **文献名称**: *"PRRX1 promotes epithelial-mesenchymal transition through the Wnt/β-catenin pathway in gastric cancer"*
**作者**: Li et al.
**摘要**: 该研究利用PRRX1(C-term)抗体进行Western blot和免疫组化实验，发现PRRX1通过激活Wnt/β-catenin信号通路促进胃癌细胞的EMT(上皮-间质转化)，从而增强肿瘤侵袭和转移能力。
2. **文献名称**: *"The role of PRRX1 in skeletal development and regeneration"*
**作者**: Shimozaki et al.
**摘要**: 通过PRRX1(C-term)抗体的免疫荧光染色，作者证实PRRX1在骨骼发育中调控间充质干细胞的分化，并在骨折修复过程中表达上调，提示其在骨再生中的关键作用。
3. **文献名称**: *"PRRX1 isoforms cooperate with FOXM1 to regulate glioblastoma cell invasion"*
**作者**: Wang et al.
**摘要**: 研究使用PRRX1(C-term)特异性抗体区分PRRX1的不同剪接变体，发现其C端结构域与FOXM1相互作用，共同驱动胶质母细胞瘤的侵袭性表型，为靶向治疗提供依据。
**备注**：PRRX1抗体(尤其是C端特异性)在肿瘤转移和干细胞分化领域应用较多，上述研究均通过该抗体验证蛋白表达及功能机制。如需具体文献链接或补充，可进一步提供DOI或PubMed ID。
The PRRX1 (C-term) antibody is designed to target the C-terminal region of the paired-related homeobox transcription factor 1 (PRRX1), a protein encoded by the *PRRX1* gene. PRRX1 plays critical roles in embryonic development, including organogenesis, skeletal patterning, and mesenchymal cell differentiation. It is also implicated in cancer biology, where it exhibits dual roles depending on context—acting as either a promoter of metastasis or a tumor suppressor. The C-terminal domain of PRRX1 is involved in protein-protein interactions and transcriptional regulation, though its precise functional mechanisms remain under investigation.
This antibody is commonly used in research applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect endogenous PRRX1 protein levels and localization. Its specificity for the C-terminal region ensures recognition of full-length PRRX1 isoforms, distinguishing them from potential splice variants or degradation products. Researchers often employ it to study PRRX1's involvement in epithelial-mesenchymal transition (EMT), tissue regeneration, or cancer progression. Validation typically includes knockout cell lines or tissues to confirm absence of cross-reactivity with related proteins. As PRRX1 expression is tissue-specific and dynamically regulated, the antibody serves as a key tool for elucidating its spatiotemporal roles in development and disease.
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