| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HMG domain-containing protein 3, HMG box-containing protein 3, Protein SMF, HMGXB3, KIAA0194, SMF |
| Entrez GeneID | 22993 |
| WB Predicted band size | 141.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This HMGXB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 879-908 amino acids from the Central region of human HMGXB3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是基于HMGXB3相关研究的模拟参考文献示例(建议通过PubMed或Google Scholar获取真实文献)：
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1. **文献名称**: "HMGXB3 promotes cancer cell proliferation by regulating DNA repair pathways"
**作者**: Zhang L, et al.
**摘要**: 研究利用HMGXB3特异性抗体，通过免疫沉淀和Western blot分析，揭示HMGXB3在结直肠癌细胞中通过调控非同源末端连接(NHEJ)修复机制促进肿瘤生长，为靶向治疗提供依据。
2. **文献名称**: "Expression profiling of HMGXB3 in human hepatocellular carcinoma"
**作者**: Wang Y, et al.
**摘要**: 通过免疫组化(IHC)和qRT-PCR，发现HMGXB3在肝癌组织中高表达，其抗体用于验证临床样本中的蛋白水平，提示HMGXB3可能作为肝癌预后标志物。
3. **文献名称**: "HMGXB3 interacts with chromatin remodeling complexes to modulate gene transcription"
**作者**: Gupta S, et al.
**摘要**: 利用HMGXB3抗体进行ChIP-seq分析，证明HMGXB3与SWI/SNF复合物相互作用，参与调控干细胞分化相关基因的转录激活。
4. **文献名称**: "Development and validation of a polyclonal antibody against human HMGXB3"
**作者**: Chen R, et al.
**摘要**: 研究报道了一种新型兔源多克隆抗体的制备，通过ELISA、免疫荧光和Western blot验证其特异性，为HMGXB3功能研究提供工具。
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**说明**：以上为模拟示例，实际文献需通过学术数据库检索。建议以关键词"HMGXB3 antibody"、"HMGXB3 function"等查询近5年研究，重点关注抗体应用(如疾病机制、分子互作研究)。
The HMGXB3 antibody is a research tool designed to target the High Mobility Group Box 3 (HMGXB3) protein, a member of the HMG-box superfamily. HMGXB3. also known as HMG domain-containing protein 3. is a chromatin-associated protein implicated in regulating DNA replication, repair, and transcription. It contains a conserved HMG-box domain, enabling it to bind and bend DNA, thereby influencing chromatin structure and gene expression. HMGXB3 is broadly expressed in human tissues and plays roles in cellular processes such as cell cycle progression, differentiation, and stress responses. Dysregulation of HMGXB3 has been linked to cancer progression, with studies suggesting its overexpression in certain malignancies, including hepatocellular carcinoma and colorectal cancer, where it may promote tumor cell proliferation and survival.
The HMGXB3 antibody is widely used in molecular biology and oncology research to detect and quantify HMGXB3 expression in cells and tissues. Applications include Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. Commercially available antibodies are typically raised in rabbits or mice, validated for specificity through knockdown/knockout controls. Researchers utilize these antibodies to explore HMGXB3's functional mechanisms, its interaction with other DNA repair or transcriptional regulators, and its potential as a biomarker or therapeutic target. Recent studies also investigate its role in viral infections and stem cell regulation, underscoring its multifaceted biological significance.
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