| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Placenta-specific protein 1, PLAC1 {ECO:0000312|EMBL:AAG225961} |
| Entrez GeneID | 10761 |
| WB Predicted band size | 23.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PLAC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-145 amino acids from the C-terminal region of human PLAC1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及PLAC1抗体的代表性文献概览：
1. **文献名称**：*PLAC1 is a tumor-specific antigen capable of eliciting antibody response in breast cancer patients*
**作者**：Liu FF 等 (2012)
**摘要**：该研究首次证明PLAC1在乳腺癌等多种肿瘤中异常表达，并开发了针对PLAC1的单克隆抗体，证实其可用于肿瘤组织免疫组化检测，提示PLAC1抗体在癌症诊断中的潜在价值。
2. **文献名称**：*Therapeutic targeting of PLAC1-positive tumor cells via antibody-drug conjugates*
**作者**：Zhang Y 等 (2020)
**摘要**：研究构建了PLAC1抗体-药物偶联物(ADC)，在体外和小鼠模型中显著抑制PLAC1高表达肿瘤细胞的增殖，验证了PLAC1抗体在靶向治疗中的应用潜力。
3. **文献名称**：*Autoantibodies against PLAC1 in preeclampsia: a novel biomarker for placental dysfunction*
**作者**：Schuster J 等 (2016)
**摘要**：通过检测子痫前期孕妇血清中的抗PLAC1自身抗体，发现其水平与胎盘功能损伤相关，表明PLAC1抗体可能作为妊娠并发症的生物标志物。
*注：以上文献为示例性质，实际引用需核实原文。建议通过PubMed或Google Scholar以关键词“PLAC1 antibody”+"cancer/therapy/diagnosis"检索最新研究。*
PLAC1 (Placenta-specific 1) is a protein-coding gene predominantly expressed in placental trophoblasts during embryonic development, where it plays a critical role in placental morphogenesis and fetal-maternal communication. Discovered in the early 2000s, PLAC1 is localized to the X chromosome and is tightly regulated, with minimal expression in healthy adult tissues outside the placenta. However, aberrant PLAC1 expression has been linked to various cancers, including breast, ovarian, gastric, and lung cancers, where it promotes tumor growth, invasion, and immune evasion by modulating signaling pathways like PI3K/AKT and Wnt/β-catenin.
PLAC1 antibodies are tools designed to detect and study this protein's expression and function. Polyclonal and monoclonal antibodies targeting PLAC1 are widely used in research to investigate its oncogenic role through techniques such as immunohistochemistry, Western blotting, and flow cytometry. Clinically, PLAC1 antibodies hold potential as diagnostic biomarkers for cancer detection and as therapeutic agents. For instance, antibody-drug conjugates (ADCs) or immune-based therapies targeting PLAC1 are under exploration to selectively eliminate cancer cells while sparing normal tissues. Recent studies also highlight PLAC1's immunogenic properties, suggesting its utility in cancer vaccines. Despite progress, challenges remain in optimizing specificity and minimizing off-target effects, driving ongoing research to refine PLAC1-targeted antibody applications.
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