Rabbit Polyclonal F12(N-term) Antibody

The F12 (N-term) antibody specifically targets the N-terminal region of human coagulation Factor XII (FXII), a plasma glycoprotein encoded by the *F12* gene. FXII, also known as Hageman factor, is a serine protease zymogen that plays a dual role in blood coagulation and inflammatory responses. Upon contact with negatively charged surfaces (e.g., collagen, polyphosphates), FXII undergoes autoactivation to FXIIa, initiating the intrinsic coagulation cascade and triggering kallikrein-mediated bradykinin production. The N-terminal region of FXII contains critical domains for its procoagulant and proinflammatory functions, including fibronectin-binding and collagen-binding sites. The F12 (N-term) antibody is widely used in research to study FXII expression, localization, and activation in physiological and pathological contexts, such as thrombosis, hereditary angioedema, and inflammatory disorders. Its specificity for the N-terminal epitope enables detection of full-length FXII and differentiation from proteolytic fragments. This antibody is valuable in techniques like Western blotting, immunohistochemistry, and ELISA, aiding investigations into FXII's role in hemostasis, innate immunity, and disease mechanisms.