| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ras-related protein Rab-40C, Rar-like protein, Ras-like protein family member 8C, SOCS box-containing protein RAR3, RAB40C, RARL, RASL8C |
| Entrez GeneID | 57799 |
| WB Predicted band size | 31.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This RAB40C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-148 amino acids from the Central region of human RAB40C. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3条关于RAB40C抗体的参考文献(注：以下为合理虚构内容，实际文献需通过数据库验证)：
1. **文献名称**：*"Development and Validation of a Novel RAB40C-Specific Antibody for Studying Vesicular Trafficking"*
**作者**：Chen, L. et al.
**摘要**：本研究报道了一种高特异性RAB40C多克隆抗体的开发，并通过Western blot和免疫荧光验证其在多种细胞系中的反应性。研究发现RAB40C在调节溶酶体相关囊泡运输中起关键作用，尤其在HeLa细胞中敲低RAB40C会导致蛋白质降解异常。
2. **文献名称**：*"RAB40C Expression Correlates with Poor Prognosis in Colorectal Cancer and Promotes Tumor Invasion"*
**作者**：Tanaka, K. et al.
**摘要**：通过免疫组化分析，该研究利用商业化RAB40C抗体揭示了其在结直肠癌组织中高表达，并与患者生存率负相关。功能实验表明，RAB40C通过调控EGFR信号通路促进肿瘤细胞迁移和侵袭。
3. **文献名称**：*"RAB40C Interacts with SMURF1 to Modulate TGF-β/BMP Signaling in Osteoblast Differentiation"*
**作者**：Zhang, Y. et al.
**摘要**：研究使用CRISPR/Cas9和RAB40C抗体进行共免疫沉淀，发现RAB40C与泛素连接酶SMURF1相互作用，负调控BMP信号通路，影响成骨细胞分化，为骨代谢疾病提供了潜在治疗靶点。
如需真实文献，建议在PubMed或Google Scholar中检索关键词“RAB40C antibody”或“RAB40C function”。
The RAB40C antibody is a key tool for studying the RAB40C protein, a member of the RAB GTPase family involved in regulating intracellular vesicular trafficking and membrane dynamics. RAB40C, part of the RAS oncogene superfamily, functions as a molecular switch, cycling between active GTP-bound and inactive GDP-bound states to control cargo transport, organelle positioning, and secretory pathways. Unlike other RAB GTPases, RAB40C uniquely contains a conserved SOCS box domain, suggesting roles in protein degradation via E3 ubiquitin ligase complexes. It is implicated in exosome release, cytokinesis, and extracellular matrix remodeling, with emerging links to cancers, neurodegenerative disorders, and connective tissue diseases.
RAB40C antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant proteins. These antibodies enable detection and localization of RAB40C in techniques such as Western blotting, immunofluorescence, and immunohistochemistry. Validation includes testing specificity (e.g., siRNA knockdown controls) and cross-reactivity checks. Commercial RAB40C antibodies vary in clonality (monoclonal/polyclonal) and conjugation tags (e.g., HRP, FITC). Researchers use them to explore RAB40C's interaction networks, post-translational modifications, and dysregulation in pathological contexts, aiding efforts to target RAB-mediated pathways therapeutically.
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