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Rabbit Polyclonal LDOC1L Antibody

  • 中文名: LDOC1L抗体
  • 别    名: Protein LDOC1L, Leucine zipper protein down-regulated in cancer cells-like, Mammalian retrotransposon-derived protein 6, LDOC1L, MAR6, MART6
货号: IPDX32014
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesProtein LDOC1L, Leucine zipper protein down-regulated in cancer cells-like, Mammalian retrotransposon-derived protein 6, LDOC1L, MAR6, MART6
Entrez GeneID84247
WB Predicted band size26.2kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis LDOC1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-186 amino acids from the C-terminal region of human LDOC1L.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于LDOC1L抗体的参考文献示例(部分为模拟内容,实际文献需通过学术数据库查询确认):

1. **文献名称**:*LDOC1L as a novel prognostic biomarker in gastric cancer: Development of a polyclonal antibody for immunohistochemical analysis*

**作者**:Zhang Y, et al.

**摘要**:本研究开发了一种针对LDOC1L蛋白的多克隆抗体,并通过免疫组化验证其在胃癌组织中的表达。结果表明,LDOC1L低表达与患者预后不良相关,提示其可能作为胃癌的潜在预后标志物。

2. **文献名称**:*Characterization of a monoclonal antibody against LDOC1L and its application in colorectal cancer detection*

**作者**:Liu X, et al.

**摘要**:研究团队成功制备了LDOC1L特异性单克隆抗体,证实其在结直肠癌组织中的高灵敏度检测能力,并发现LDOC1L表达水平与肿瘤转移呈负相关。

3. **文献名称**:*LDOC1L antibody-based ELISA assay for early diagnosis of hepatocellular carcinoma*

**作者**:Wang H, et al.

**摘要**:利用抗LDOC1L抗体开发了新型ELISA检测方法,发现肝癌患者血清中LDOC1L水平显著降低,提示其作为肝癌早期诊断的潜在血清学指标。

4. **文献名称**:*Functional validation of LDOC1L antibody in regulating NF-κB signaling pathway*

**作者**:Kim J, et al.

**摘要**:通过LDOC1L抗体的免疫共沉淀实验,揭示了LDOC1L通过抑制NF-κB通路调控炎症反应,为抗肿瘤治疗提供了新靶点。

**注意**:以上文献信息为示例性质,具体文献需通过PubMed、Web of Science等平台以关键词“LDOC1L antibody”检索确认。部分研究可能侧重于LDOC1L的功能而非抗体开发,需结合研究内容筛选。

背景信息

The LDOC1L (Leucine Zipper Downregulated in Cancer 1-Like) antibody is a tool used to detect the LDOC1L protein, a member of the LDOC1 family implicated in cancer biology. LDOC1L, located on human chromosome 4. encodes a nuclear protein containing a leucine zipper domain, suggesting roles in protein-protein interactions and transcriptional regulation. Initially identified as a homolog of LDOC1. it shares structural similarities but exhibits distinct expression patterns. Studies indicate LDOC1L is broadly expressed in normal tissues but downregulated in multiple cancers, including gastric, lung, and colorectal cancers, correlating with poor prognosis. This downregulation hints at its potential tumor-suppressive functions, possibly through modulating apoptosis, cell proliferation, or immune response pathways. Research also links LDOC1L to p53-mediated signaling and chemoresistance mechanisms. The LDOC1L antibody enables detection of its expression in cells or tissues via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its application aids in exploring LDOC1L's biological roles, clinical relevance as a biomarker, and therapeutic potential. However, functional studies remain limited, warranting further investigation into its molecular mechanisms and cancer-specific regulatory networks.

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