| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Olfactory receptor 10AD1, Olfactory receptor OR12-1, OR10AD1, OR10AD1P |
| Entrez GeneID | 121275 |
| WB Predicted band size | 35.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This OR10AD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-177 amino acids from the Central region of human OR10AD1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于OR10AD1抗体的假设性参考文献示例(实际文献可能需要通过学术数据库进一步检索)：
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1. **文献名称**: *"Characterization of OR10AD1 Expression in Human Olfactory Epithelium Using a Novel Polyclonal Antibody"*
**作者**: Smith J, et al.
**摘要**: 本研究开发了一种针对OR10AD1的特异性多克隆抗体，通过免疫组化验证其在人类嗅觉上皮中的选择性表达。抗体验证显示与OR10AD1的高亲和力，无交叉反应性，为嗅觉受体功能研究提供了工具。
2. **文献名称**: *"Antibody-Based Profiling of Ectopic Olfactory Receptors in Non-Chemosensory Tissues"*
**作者**: Lee H, et al.
**摘要**: 文章利用商业化OR10AD1抗体检测其在睾丸和肺组织中的表达，探讨其在非嗅觉器官中的潜在生理作用。研究强调了抗体特异性验证的重要性，并提供了OR10AD1蛋白定位的数据。
3. **文献名称**: *"High-Throughput Screening of Olfactory Receptor Antibodies for Biomedical Applications"*
**作者**: Zhang Y, et al.
**摘要**: 本研究筛选了针对多种嗅觉受体(包括OR10AD1)的单克隆抗体，通过流式细胞术和Western blot验证其适用性。OR10AD1抗体被用于探索受体与癌症细胞迁移的关联。
4. **文献名称**: *"Technical Challenges in Targeting Olfactory Receptors: A Case Study of OR10AD1"*
**作者**: Müller R, et al.
**摘要**: 文章讨论了开发OR10AD1抗体的技术难点，如抗原表位选择和跨物种反应性差异，并通过质谱分析证实抗体的靶标特异性。
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**注意**：以上文献为示例性内容，实际研究中OR10AD1抗体的相关文献可能有限。建议通过PubMed、Google Scholar等平台，结合关键词“OR10AD1 antibody”或“OR10AD1 immunohistochemistry”检索最新成果。部分研究可能隐含在嗅觉受体家族或GPCR抗体开发的文献中。
The OR10AD1 antibody is a research tool designed to detect and study the olfactory receptor 10AD1 (OR10AD1), a member of the olfactory receptor (OR) family. ORs are G protein-coupled receptors (GPCRs) primarily involved in detecting odorant molecules, playing a critical role in the olfactory system. OR10AD1. encoded by the OR10AD1 gene located on human chromosome 11. is part of the OR10A subfamily. While its specific ligand remains unidentified, it is presumed to contribute to odorant recognition and signal transduction.
Antibodies targeting OR10AD1 are used to investigate its expression patterns, cellular localization, and potential roles in non-olfactory tissues, where some ORs have been implicated in physiological or pathological processes (e.g., cancer, metabolic regulation). These antibodies are typically developed in host species like rabbits or mice using immunogenic peptide sequences derived from the receptor’s structure. Validation methods include Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF).
Challenges with OR10AD1 antibodies include ensuring specificity due to the high homology among OR family members. Researchers often use knockout controls or orthogonal techniques to confirm target engagement. Commercial availability is limited, and antibodies are primarily utilized in basic research to explore OR10AD1’s functional relevance in health and disease. Emerging studies suggest ORs may have therapeutic potential, driving interest in tools like OR10AD1 antibodies for mechanistic insights.
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