| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | NS5ATP1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human HIBADH |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于PCMTD1(N-term)抗体的3篇假设性参考文献示例，基于典型研究场景整理：
---
1. **文献名称**：*"Characterization of PCMTD1 as a novel methyltransferase involved in cellular stress response"*
**作者**：Smith et al. (2020)
**摘要**：本研究首次鉴定了PCMTD1的甲基转移酶活性，并开发了针对其N端结构域的多克隆抗体。通过Western blot和免疫荧光实验，发现PCMTD1在氧化应激条件下易位至细胞核，提示其在应激信号通路中的作用。
2. **文献名称**：*"Development of N-terminal specific antibodies for PCMTD1 and their application in cancer biomarker discovery"*
**作者**：Lee et al. (2019)
**摘要**：报道了一种高特异性的抗PCMTD1(N-term)单克隆抗体的制备与验证。该抗体成功用于免疫组化分析，显示PCMTD1在结直肠癌组织中表达显著上调，并与患者预后相关。
3. **文献名称**：*"PCMTD1 interacts with spliceosome components via its N-terminal domain: insights from co-immunoprecipitation assays"*
**作者**：Zhang et al. (2021)
**摘要**：利用N端特异性抗体进行免疫共沉淀实验，发现PCMTD1通过N端结构域与剪接体蛋白相互作用，提示其在RNA加工中的潜在功能。抗体特异性经敲除细胞系验证。
---
**说明**：以上文献为示例性质，实际引用时需通过PubMed、Google Scholar等平台以“PCMTD1 antibody”、“PCMTD1 N-terminal”为关键词检索真实文献。若研究较少，可扩展至涉及PCMTD1功能研究的论文，并在方法部分查找抗体使用信息。
The PCMTD1 (N-term) antibody is designed to target the N-terminal region of PCMTD1 (Protein-L-isoaspartate (D-aspartate) O-methyltransferase domain-containing protein 1), a protein implicated in post-translational modification and repair of damaged proteins. PCMTD1 belongs to the methyltransferase superfamily and is thought to play a role in protein stability by catalyzing the methylation of abnormal L-isoaspartyl residues, which arise spontaneously from asparagine or aspartic acid residues during aging or under stress. This methylation marks damaged proteins for repair or degradation, a critical process in maintaining cellular homeostasis, particularly in long-lived cells or under conditions of oxidative stress.
The antibody is commonly used in research to study PCMTD1 expression, localization, and function in various biological contexts. Its specificity for the N-terminal region allows detection of full-length or truncated forms of the protein, aiding investigations into its regulatory mechanisms or involvement in disease pathways. PCMTD1 has been linked to neurodegenerative disorders and cancer, where protein misfolding or oxidative damage is prevalent. Researchers utilize this antibody in techniques such as Western blotting, immunofluorescence, or immunoprecipitation to explore PCMTD1's interactions, tissue distribution, and potential therapeutic relevance. Validation typically includes knockout cell lines or tissues to confirm specificity, ensuring reliable detection across experimental models.
×
