| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 550, ZNF550 |
| Entrez GeneID | 162972 |
| WB Predicted band size | 48.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZNF550 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-94 amino acids from the N-terminal region of human ZNF550. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF550 (N-term)抗体的假设性参考文献示例(请注意，以下内容为模拟示例，实际文献需通过学术数据库检索确认)：
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1. **文献名称**：*ZNF550 Expression in Colorectal Cancer: Prognostic Implications*
**作者**：Smith J, et al.
**摘要**：本研究通过免疫组化(使用ZNF550 N-term抗体)分析了ZNF550在结直肠癌组织中的表达水平，发现其高表达与患者不良预后显著相关，提示ZNF550可能作为潜在的肿瘤标志物。
2. **文献名称**：*Functional Characterization of ZNF550 in Neuronal Differentiation*
**作者**：Zhang L, et al.
**摘要**：利用ZNF550 N-term抗体进行Western Blot和染色质免疫沉淀(ChIP-seq)，揭示了ZNF550在神经元分化过程中调控特定靶基因的DNA结合模式，并影响分化进程。
3. **文献名称**：*High-Throughput Screening of Zinc Finger Proteins in Human Cell Lines*
**作者**：Lee S, et al.
**摘要**：通过ZNF550 N-term抗体对多种人类细胞系进行蛋白质印迹分析，系统鉴定了ZNF550的表达谱，发现其在胚胎干细胞中表达显著上调，提示其可能参与干性维持。
4. **文献名称**：*ZNF550 Interacts with p53 Signaling Pathway in Cellular Stress Response*
**作者**：Johnson R, et al.
**摘要**：使用ZNF550 N-term抗体进行免疫共沉淀实验，证实ZNF550与p53蛋白存在相互作用，可能在DNA损伤应激反应中协同调控下游基因转录。
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**建议**：实际研究中，可通过PubMed、Google Scholar等平台，以关键词“ZNF550 antibody”、“ZNF550 N-terminal”或抗体货号(如Abcam、CST等厂商提供)检索最新文献。部分抗体厂商官网也会列出用户发表的引用数据。
The ZNF550 (N-term) antibody is designed to target the N-terminal region of Zinc Finger Protein 550 (ZNF550), a member of the Krüppel-associated box (KRAB)-containing zinc finger protein (ZFP) family. ZNF550 is characterized by multiple C2H2-type zinc finger motifs, which facilitate sequence-specific DNA binding, and a KRAB domain at the N-terminus that often mediates protein-protein interactions, particularly with transcriptional repressors. These features suggest ZNF550 may function as a transcription regulator, potentially involved in chromatin remodeling or gene silencing. The N-terminal region, containing the KRAB domain, is critical for recruiting co-repressors like TRIM28/KAP1 to establish repressive chromatin states.
The ZNF550 (N-term) antibody is commonly used in research applications (e.g., Western blotting, immunofluorescence, ChIP) to study the protein’s expression, localization, and molecular interactions. Its specificity for the N-terminus allows detection of full-length ZNF550 or isoforms retaining this domain. While ZNF550’s exact biological roles remain under investigation, it has been implicated in cellular differentiation, proliferation, and cancer pathways. Dysregulation of ZNF family members is frequently linked to tumorigenesis, making this antibody a tool for exploring ZNF550’s potential involvement in disease mechanisms. Commercial versions are typically raised in rabbits or mice, with validation across human, mouse, or rat samples depending on the product.
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