| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Potassium voltage-gated channel subfamily F member 1, Voltage-gated potassium channel subunit Kv51, kH1, KCNF1 |
| Entrez GeneID | 3754 |
| WB Predicted band size | 55.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This KCNF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-221 amino acids from the Central region of human KCNF1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于KCNF1抗体的参考文献(文献信息为模拟示例，实际引用请核实数据库)：
1. **文献名称**: "Characterization of KCNF1 potassium channel expression in mammalian brain using a novel monoclonal antibody"
**作者**: Smith J, et al.
**摘要**: 开发了一种特异性识别KCNF1蛋白的单克隆抗体，通过免疫印迹和免疫组化验证其在啮齿类及人类脑组织中的表达，发现KCNF1主要分布于海马和皮层神经元。
2. **文献名称**: "Role of KCNF1 in neuronal excitability: Insights from antibody-mediated knockdown experiments"
**作者**: Lee H, et al.
**摘要**: 利用KCNF1多克隆抗体进行蛋白功能研究，发现抑制KCNF1会增强神经元兴奋性，提示其在调节动作电位复极化中的关键作用。
3. **文献名称**: "Validation of commercial KCNF1 antibodies for immunohistochemical applications in neurodegenerative disease models"
**作者**: Garcia R, et al.
**摘要**: 评估了多种市售KCNF1抗体的特异性，筛选出适用于阿尔茨海默病模型小鼠脑组织染色的抗体，并发现KCNF1表达水平与疾病进展相关。
(注：以上文献为示例，实际研究中建议通过PubMed或Google Scholar以“KCNF1 antibody”为关键词检索最新文章。)
The KCNF1 antibody is a research tool designed to detect and study the potassium voltage-gated channel subfamily F member 1 (KCNF1), a protein encoded by the *KCNF1* gene in humans. KCNF1 belongs to the voltage-gated potassium (Kv) channel family, which regulates neuronal excitability and cardiac action potentials by controlling potassium ion flow across cell membranes. Structurally, KCNF1 forms tetrameric channels, typically functioning as modulatory subunits that co-assemble with other Kv α-subunits to influence channel kinetics, stability, or trafficking. While its exact physiological role remains less characterized compared to other Kv channels, KCNF1 is implicated in maintaining electrical stability in excitable tissues, particularly in the brain and heart.
Research involving KCNF1 antibodies focuses on elucidating its expression patterns, interaction partners, and pathological relevance. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to map KCNF1 distribution in tissues or assess its expression changes in disease models. Dysregulation of Kv channels, including KCNF1. has been linked to neurological disorders (e.g., epilepsy, ataxia) and cardiac arrhythmias, driving interest in KCNF1 as a potential therapeutic target. However, challenges such as antibody specificity and cross-reactivity with homologous Kv proteins require careful validation. Commercially available KCNF1 antibodies are typically raised against specific epitopes (e.g., N-terminal or C-terminal regions), enabling targeted studies of its structure-function relationships and disease mechanisms.
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