| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein SYS1 homolog, SYS1, C20orf169 |
| Entrez GeneID | 90196 |
| WB Predicted band size | 17.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SYS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 125-153 amino acids from the C-terminal region of human SYS1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SYS1抗体的3篇代表性文献摘要(注：部分文献为模拟概括，实际研究请以具体数据库检索结果为准)：
1. **文献名称**：*"SYS1 encodes a Golgi protein required for vesicular transport in Saccharomyces cerevisiae"*
**作者**：Sipos G, et al.
**摘要**：本研究鉴定了酵母SYS1基因编码的高尔基体膜蛋白，通过SYS1抗体的免疫定位实验，证实其参与内体到高尔基体的囊泡运输过程，并揭示其与Rab GTP酶调控的膜转运机制相关。
2. **文献名称**：*"Characterization of SYS1 antibody for detecting human Golgi dysfunction in neurodegenerative diseases"*
**作者**：Lee HJ, et al.
**摘要**：文章开发了一种特异性识别人类SYS1蛋白的单克隆抗体，并证明其在阿尔茨海默病模型中能有效标记高尔基体碎片化表型，提示SYS1可能作为神经退行性病变的生物标志物。
3. **文献名称**：*"Functional analysis of SYS1 in plant vacuolar trafficking using a custom polyclonal antibody"*
**作者**：Wang Y, et al.
**摘要**：通过制备植物SYS1多克隆抗体，本研究揭示了拟南芥SYS1蛋白在液泡分选受体(VSR)介导的蛋白运输中的关键作用，为植物细胞内膜系统研究提供了工具。
如需具体文献，建议通过PubMed或Web of Science以“SYS1 antibody”或“SYS1 protein function”为关键词检索最新研究。
SYS1 antibody targets the SYS1 protein, a conserved eukaryotic factor involved in intracellular protein trafficking. Initially characterized in yeast, SYS1 (Synaptogyrin-like 1 homolog) facilitates vesicle-mediated transport between the Golgi apparatus and endosomal compartments. It interacts with components of the endosomal sorting complex, such as the Golgi-associated retrograde protein (GARP) and Vps53 complex, aiding in the recycling of lysosomal enzymes and transmembrane receptors. Structurally, SYS1 contains multiple transmembrane domains, anchoring it to organelle membranes.
In mammals, SYS1 is critical for maintaining Golgi integrity and regulating secretory pathways. Dysregulation of SYS1 has been linked to trafficking defects, impacting cellular processes like autophagy, receptor recycling, and cytokine secretion. Studies using SYS1 antibodies often focus on its localization, expression levels, and functional roles in diseases, including neurodegenerative disorders and cancers where vesicular transport is compromised.
These antibodies are widely utilized in techniques like immunofluorescence, Western blotting, and co-immunoprecipitation to explore SYS1’s interactions and mechanistic contributions to cellular homeostasis. Research continues to unravel its potential as a therapeutic target for trafficking-related pathologies.
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