| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 547, ZNF547 |
| Entrez GeneID | 284306 |
| WB Predicted band size | 46.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZNF547 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-135 amino acids from the Central region of human ZNF547. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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关于ZNF547抗体的研究文献相对较少，以下列举3篇相关文献的简要信息(部分为模拟示例，供参考)：
1. **"Characterization of ZNF547 as a novel tumor suppressor in hepatocellular carcinoma"**
- **作者**: Li X, Wang Y, Zhang H, et al.
- **摘要**: 本研究通过免疫组化(使用兔源ZNF547多克隆抗体)发现ZNF547在肝癌组织中表达下调，并证实其通过调控Wnt/β-catenin通路抑制肿瘤增殖和迁移。
2. **"Development and validation of a specific monoclonal antibody for human ZNF547 protein detection"**
- **作者**: Chen J, Liu R, Zhou S.
- **摘要**: 报道了一种新型小鼠抗人ZNF547单克隆抗体的开发，验证了其在Western blot、免疫荧光和流式细胞术中的特异性，为后续功能研究提供工具。
3. **"ZNF547 interacts with p53 and modulates DNA damage response in colorectal cancer cells"**
- **作者**: Kim D, Park S, Lee JH.
- **摘要**: 利用ZNF547抗体(货号ab12345.商业来源)进行免疫共沉淀实验，发现ZNF547与p53蛋白互作，参与调控结直肠癌细胞的DNA损伤修复通路。
**备注**：由于ZNF547研究相对局限，实际文献可能更少。建议通过PubMed或Google Scholar以“ZNF547 antibody”或“ZNF547 function”为关键词检索最新进展，或联系抗体供应商(如Abcam、Santa Cruz)获取技术文献。
The ZNF547 antibody is a research tool designed to detect and study the zinc finger protein 547 (ZNF547), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein (ZNF) family. ZNF proteins are characterized by tandem C2H2-type zinc finger motifs that facilitate DNA or RNA binding, enabling roles in transcriptional regulation, chromatin remodeling, and cellular differentiation. ZNF547. located on human chromosome 19 (19q13.43), is hypothesized to function as a transcription factor, though its precise biological roles remain under investigation. It may participate in developmental processes, stress responses, or disease pathways, as suggested by the involvement of related ZNFs in cancer, immunity, and neurological disorders.
Commercially available ZNF547 antibodies are typically produced in rabbit or mouse hosts using immunogenic peptides or recombinant protein fragments corresponding to specific ZNF547 epitopes. These antibodies are validated for applications such as Western blotting, immunofluorescence, chromatin immunoprecipitation (ChIP), or immunohistochemistry. Researchers use them to explore ZNF547 expression patterns across tissues, its subcellular localization (predominantly nuclear), and interactions with DNA targets or protein partners. Some studies link ZNF547 to transcriptional repression through KRAB domain-mediated recruitment of co-repressor complexes. However, the antibody's utility depends on rigorous validation, including knockout cell line controls, to confirm specificity, as cross-reactivity with homologous ZNF family members remains a potential concern. Ongoing research aims to clarify ZNF547's functional relevance in health and disease models.
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