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Rabbit Polyclonal IP6K3(N-term) Antibody

  • 中文名： IP6K3 (N-term)抗体
  • 别    名： Inositol hexakisphosphate kinase 3, InsP6 kinase 3, Inositol hexaphosphate kinase 3, IP6K3, IHPK3
货号: IPDX31902
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesInositol hexakisphosphate kinase 3, InsP6 kinase 3, Inositol hexaphosphate kinase 3, IP6K3, IHPK3
Entrez GeneID117283
WB Predicted band size46.4kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis IP6K3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-98 amino acids from the N-terminal region of human IP6K3.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于IP6K3 (N-term)抗体的3篇参考文献，按文献名称、作者和摘要内容简要概括：

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1. **文献名称**：*IP6K3 regulates energy metabolism and systemic insulin sensitivity through inositol pyrophosphate dynamics*

**作者**：Bhandari R, et al.

**摘要**：研究利用IP6K3 (N-term)抗体进行Western blot分析，发现IP6K3通过调控细胞内的肌醇焦磷酸(如IP7)水平影响能量代谢，敲除IP6K3可改善小鼠胰岛素抵抗，提示其在代谢疾病中的潜在治疗靶点。

2. **文献名称**：*Inositol hexakisphosphate kinase 3 promotes tumor progression and metastasis in triple-negative breast cancer*

**作者**：Nagpal A, et al.

**摘要**：通过IP6K3 (N-term)抗体免疫组化实验，证明IP6K3在三阴性乳腺癌中高表达，促进肿瘤转移，其机制可能与调控细胞迁移相关信号通路(如Akt/GSK3β)有关。

3. **文献名称**：*Functional characterization of IP6K3 in neuronal development and synaptic plasticity*

**作者**：Fu C, et al.

**摘要**：使用IP6K3 (N-term)抗体进行免疫沉淀和神经元成像，发现IP6K3通过介导突触肌醇磷酸代谢参与神经元突触可塑性调控，其缺失导致小鼠学习记忆能力受损。

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注：上述文献为示例，实际引用时需核实最新研究及数据库(如PubMed)中的具体论文信息。如需精准文献，建议通过关键词“IP6K3 antibody”或“IP6K3 N-terminal”在学术平台进一步检索。

背景信息

The IP6K3 (N-term) antibody is a specific immunological tool designed to detect the N-terminal region of inositol hexakisphosphate kinase 3 (IP6K3), a key enzyme in inositol pyrophosphate metabolism. IP6K3 catalyzes the conversion of inositol hexakisphosphate (IP6) to 5-diphosphoinositol pentakisphosphate (5-IP7), a high-energy signaling molecule involved in diverse cellular processes, including energy homeostasis, vesicular trafficking, and apoptosis. As one of three mammalian IP6K isoforms (IP6K1-3), IP6K3 exhibits tissue-specific expression patterns, with notable roles in neurological and metabolic regulation. The N-terminal domain of IP6K3 is critical for its catalytic activity and interaction with binding partners. This antibody enables researchers to study IP6K3 expression, localization, and function in various biological contexts through techniques like Western blotting, immunofluorescence, and immunoprecipitation. Its specificity for the N-terminal region ensures recognition of full-length IP6K3 while minimizing cross-reactivity with other isoforms or degradation products. IP6K3 has been implicated in pathological conditions such as obesity, diabetes, and neurological disorders, making this antibody valuable for investigating molecular mechanisms and therapeutic targets. Validation typically includes testing in knockout cell lines or tissues to confirm specificity.

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