| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Dehydrogenase/reductase SDR family member 1, 11--, DHRS1 |
| Entrez GeneID | 115817 |
| WB Predicted band size | 33.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This DHRS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-209 amino acids from the Central region of human DHRS1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于DHRS1抗体的假设性参考文献示例(请注意，实际文献可能需要通过学术数据库验证)：
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1. **文献名称**：*Characterization of DHRS1 expression in human liver tissues using a novel polyclonal antibody*
**作者**：Smith J, et al.
**摘要**：本研究开发了一种针对人源DHRS1蛋白的多克隆抗体，并通过Western blot和免疫组织化学验证其特异性。结果显示DHRS1在肝脏组织中高表达，提示其在脂质代谢中的潜在作用。
2. **文献名称**：*DHRS1 as a biomarker in colorectal cancer: Validation of a commercial antibody for immunohistochemical analysis*
**作者**：Zhang Y, et al.
**摘要**：文章评估了某商业DHRS1抗体在结直肠癌组织中的适用性，发现DHRS1低表达与患者预后不良相关。实验通过免疫荧光和流式细胞术确认抗体的特异性。
3. **文献名称**：*Functional role of DHRS1 in stem cell differentiation: Insights from antibody-mediated protein localization*
**作者**：Lee S, et al.
**摘要**：利用定制的小鼠单克隆DHRS1抗体，研究团队发现DHRS1在胚胎干细胞分化过程中定位于线粒体，并可能通过调控视黄酸代谢影响分化进程。
4. **文献名称**：*Development of a rabbit monoclonal antibody against DHRS1 and its application in renal cell carcinoma*
**作者**：Brown K, et al.
**摘要**：本文报道了一种高亲和力的兔单克隆DHRS1抗体的开发，并在肾癌细胞系中验证其结合能力。研究发现DHRS1可能通过抑制Wnt通路发挥抑癌作用。
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**说明**：
- 以上文献为示例，实际研究可能需通过PubMed、Google Scholar等平台检索。
- 建议使用关键词“DHRS1 antibody”、“DHRS1 immunohistochemistry”或结合特定研究领域(如癌症、代谢)进行精准查询。
- 若需具体文献，可提供更详细的研究背景或应用场景，以便进一步筛选。
The DHRS1 (Dehydrogenase/Reductase 1) antibody is a tool used to study the DHRS1 protein, a member of the short-chain dehydrogenase/reductase (SDR) superfamily. DHRS1 is implicated in redox reactions, lipid metabolism, and cellular detoxification processes, though its precise biological roles remain under investigation. It shares structural features with SDR enzymes, including conserved cofactor-binding motifs (e.g., NAD+/NADP+), suggesting involvement in regulating cellular redox balance.
DHRS1 antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. These antibodies enable researchers to detect DHRS1 expression levels, localization (e.g., cytoplasmic or nuclear), and interactions via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Specificity validation through knockout controls or siRNA knockdown is critical due to potential cross-reactivity with homologous SDR proteins.
Interest in DHRS1 stems from its regulatory roles in cell differentiation, apoptosis, and oxidative stress responses. Studies suggest DHRS1 may act as a tumor suppressor, with reduced expression observed in certain cancers. However, its mechanistic contributions to disease pathways remain unclear. Researchers also explore DHRS1's involvement in lipid homeostasis and metabolic disorders. The antibody thus serves as a key reagent for unraveling DHRS1's physiological and pathological significance, bridging gaps between its enzymatic activity and broader cellular functions.
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