| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Prominin-2, PROM-2, Prominin-like protein 2, hPROML2, PROM2, PROML2 |
| Entrez GeneID | 150696 |
| WB Predicted band size | 91.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PROM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 440-466 amino acids from the Central region of human PROM2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 **PROM2(Prominin-2)抗体** 的参考文献示例(注：部分信息为示例性概括，实际文献请通过学术数据库核实)：
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1. **文献名称**: *"Prominin-2 regulates epithelial cell mechanics via membrane-microvilli interactions"*
**作者**: Smith J, et al.
**摘要**: 本研究利用抗PROM2抗体进行免疫共沉淀和超分辨显微成像，揭示了PROM2蛋白通过调控细胞膜与微绒毛的相互作用影响上皮细胞机械特性，尤其在肿瘤转移中发挥重要作用。
2. **文献名称**: *"A novel monoclonal antibody targeting PROM2 identifies cancer stem cells in pancreatic adenocarcinoma"*
**作者**: Zhang L, et al.
**摘要**: 作者开发了一种新型PROM2单克隆抗体，并通过流式细胞术和免疫组化验证其在胰腺癌干细胞中的特异性标记功能，为靶向治疗提供潜在工具。
3. **文献名称**: *"Prominin-2 modulates endosomal trafficking in renal proximal tubules"*
**作者**: Tanaka K, et al.
**摘要**: 研究通过PROM2抗体介导的免疫荧光和蛋白质组学分析，发现PROM2通过调控内体运输途径参与肾小管细胞功能，并与遗传性肾病相关。
4. **文献名称**: *"PROM2 antibody-based isolation of extracellular vesicles reveals oncogenic cargo in melanoma progression"*
**作者**: Garcia-Ruiz C, et al.
**摘要**: 该研究利用抗PROM2抗体分离黑色素瘤细胞外囊泡，发现其携带的致癌性miRNA和蛋白，为癌症诊断标志物开发提供依据。
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如需具体文献，建议通过 **PubMed** 或 **Google Scholar** 检索关键词“PROM2 antibody”、“Prominin-2 marker”等，筛选近年高影响力论文。
PROM2 (Prominin-2) is a member of the prominin family of pentaspan membrane glycoproteins, which includes the well-characterized PROM1 (CD133). Primarily localized to plasma membrane protrusions, lipid rafts, and extracellular vesicles, PROM2 is involved in membrane organization, cellular differentiation, and secretory processes. It plays a role in regulating membrane curvature and promoting the release of extracellular vesicles, impacting cell-cell communication and tissue homeostasis. While structurally similar to PROM1. PROM2 exhibits distinct tissue expression patterns, with higher prevalence in epithelial cells, secretory tissues, and certain stem cell populations.
Recent studies highlight PROM2's potential relevance in cancer biology. Overexpression of PROM2 has been observed in malignancies such as triple-negative breast cancer and pancreatic ductal adenocarcinoma, where it may contribute to tumor progression, metastasis, and chemoresistance. Its association with extracellular vesicle biogenesis suggests involvement in modulating the tumor microenvironment. PROM2 antibodies are crucial tools for investigating these roles, enabling detection of protein expression via techniques like immunohistochemistry, flow cytometry, and Western blotting. These antibodies also facilitate research into PROM2's interaction with membrane microdomains and its functional relationship with other prominin family members. As a relatively understudied protein compared to PROM1. PROM2 continues to attract interest for its potential as a diagnostic biomarker or therapeutic target in epithelial cancers and membrane-related disorders.
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