| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Scavenger receptor cysteine-rich domain-containing group B protein {ECO:0000303|PubMed:12466895, ECO:0000312|HGNC:HGNC:14461}, Four scavenger receptor cysteine-rich domains-containing protein {ECO:0000312|HGNC:HGNC:14461}, S4D-SRCRB, SSC4D (HGNC:14461) |
| Entrez GeneID | 136853 |
| WB Predicted band size | 60.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SRCRB4D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-191 amino acids from the Central region of human SRCRB4D. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于SRCRB4D抗体的3篇虚构参考文献示例(实际文献需通过学术数据库检索)：
1. **文献名称**: *SRCRB4D as a novel biomarker in colorectal cancer: Expression and functional analysis*
**作者**: Smith A, et al.
**摘要**: 本研究通过开发特异性SRCRB4D单克隆抗体，揭示了该蛋白在结直肠癌组织中的高表达，并证实其通过调控Wnt/β-catenin信号通路促进肿瘤侵袭转移。
2. **文献名称**: *Targeting SRCRB4D for immunotherapy: Preclinical validation of a humanized antibody*
**作者**: Zhang L, et al.
**摘要**: 报道了一种人源化SRCRB4D抗体的开发，该抗体通过阻断SRCRB4D与肿瘤微环境中免疫抑制因子的相互作用，显著增强抗PD-1治疗的疗效。
3. **文献名称**: *Structural basis of SRCRB4D-ligand interaction revealed by cryo-EM and antibody mapping*
**作者**: Tanaka K, et al.
**摘要**: 利用冷冻电镜和SRCRB4D抗体表位定位技术，解析了SRCRB4D蛋白的构象变化及其配体结合域，为靶向药物设计提供结构基础。
4. **文献名称**: *SRCRB4D autoantibodies as a prognostic marker in inflammatory bowel disease*
**作者**: Müller S, et al.
**摘要**: 发现SRCRB4D自身抗体在克罗恩病患者血清中的水平与疾病严重程度相关，提示其作为炎症性肠病预后生物标志物的潜力。
注：以上为模拟内容，实际文献需通过PubMed、Google Scholar等平台检索确认。
The SRCRB4D antibody targets a protein belonging to the scavenger receptor cysteine-rich (SRCR) superfamily, a group of evolutionarily conserved molecules involved in immune regulation and cell-cell interactions. The SRCR domain, characterized by cysteine-rich repeats, mediates ligand binding and signal transduction. The specific antigen recognized by SRCRB4D is often associated with immune cells, particularly subsets of lymphocytes, and may play roles in pathogen recognition, apoptosis modulation, or inflammatory responses.
This antibody has been utilized in studies exploring immune cell markers, tumor microenvironments, and autoimmune disorders. Its target protein is hypothesized to function as a co-receptor or adhesion molecule, influencing immune activation or tolerance. Research applications include flow cytometry, immunohistochemistry, and Western blotting to characterize protein expression patterns in tissues or cultured cells.
SRCRB4D’s relevance extends to investigations of diseases like lymphoma, chronic inflammation, and autoimmune conditions, where dysregulation of SRCR-family proteins is implicated. Recent studies suggest its potential as a biomarker or therapeutic target, though mechanistic details remain under investigation. The antibody’s specificity and affinity are typically validated using knockout models or competitive binding assays to ensure reliability in experimental settings.
×
