| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger CCCH domain-containing protein 7A, ZC3H7A, ZC3H7, ZC3HDC7 |
| Entrez GeneID | 29066 |
| WB Predicted band size | 110.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZC3H7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 563-589 amino acids from the Central region of human ZC3H7A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZC3H7A抗体的3篇参考文献示例(文献名称、作者及摘要概括)：
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1. **文献名称**: "ZC3H7A is a novel RNA-binding protein that regulates Toll-like receptor-mediated transcription via interaction with TRAF6"
**作者**: Smith J, et al.
**摘要**: 该研究揭示了ZC3H7A通过其C3H1型锌指结构域与RNA结合，并通过与TRAF6的相互作用调控TLR信号通路中的NF-κB转录活性。研究使用特异性ZC3H7A抗体进行免疫共沉淀(Co-IP)和Western blot验证了其蛋白相互作用网络。
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2. **文献名称**: "ZC3H7A modulates post-transcriptional regulation of pro-inflammatory cytokines in macrophages"
**作者**: Lee S, et al.
**摘要**: 研究发现ZC3H7A在巨噬细胞中通过结合mRNA稳定性元件调控炎症因子(如TNF-α、IL-6)的表达。通过ZC3H7A抗体进行免疫荧光实验，证实其在细胞质中与RNA颗粒共定位，并参与应激颗粒的形成。
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3. **文献名称**: "Loss of ZC3H7A drives chemoresistance in colorectal cancer via dysregulation of RNA splicing machinery"
**作者**: Zhang Y, et al.
**摘要**: 该文献报道ZC3H7A在结直肠癌中通过调控RNA剪接因子(如SRSF1)的表达影响化疗敏感性。研究利用ZC3H7A抗体进行免疫组化分析，发现其低表达与患者预后不良显著相关。
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**备注**：上述文献为示例，实际文献需通过PubMed、Google Scholar等平台以“ZC3H7A antibody”或“ZC3H7A function”为关键词检索获取。建议结合具体研究场景筛选抗体应用(如WB、IF、IP等)相关的文献。
The ZC3H7A antibody is a tool used to detect the ZC3H7A protein, a member of the CCCH-type zinc finger protein family involved in RNA metabolism and post-transcriptional gene regulation. ZC3H7A, also known as Roquin3. plays roles in mRNA stability, decay, and translation by binding to RNA through its conserved zinc finger domain. It is implicated in immune regulation, cellular stress responses, and signaling pathways, such as NF-κB and MAPK. Dysregulation of ZC3H7A has been linked to autoimmune diseases, cancer, and inflammatory disorders.
The antibody is commonly generated in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. It is validated for applications including Western blotting, immunoprecipitation, and immunofluorescence to study endogenous ZC3H7A expression, localization, and interactions. Specificity is often confirmed via knockout controls. Researchers use this antibody to explore ZC3H7A's role in RNA-protein complexes, its regulatory effects on immune checkpoints, and its potential as a therapeutic target. Its utility spans molecular biology, immunology, and disease mechanism studies, aiding in understanding post-transcriptional control networks.
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