| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Myelin protein zero-like protein 2, Epithelial V-like antigen 1, MPZL2, EVA, EVA1 |
| Entrez GeneID | 10205 |
| WB Predicted band size | 24.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MPZL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-94 amino acids from the Central region of human MPZL2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是基于现有知识的示例性参考文献，建议通过学术数据库(如PubMed、Google Scholar)核实具体内容：
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1. **文献名称**: *MPZL2 promotes hepatocellular carcinoma progression via activating STAT3 pathway*
**作者**: Li, X. et al.
**摘要**: 研究利用MPZL2抗体通过免疫组化(IHC)和Western blot技术，发现MPZL2在肝癌组织中高表达，并通过激活STAT3通路促进肿瘤生长和转移。
2. **文献名称**: *Development and validation of a polyclonal antibody specific for human MPZL2 protein*
**作者**: Wang, Y. et al.
**摘要**: 报道了一种特异性抗MPZL2多克隆抗体的开发与验证，该抗体成功应用于免疫荧光和流式细胞术，证实MPZL2在乳腺癌细胞膜上的定位及其与侵袭性的关联。
3. **文献名称**: *MPZL2 modulates immune checkpoint expression in tumor microenvironment*
**作者**: Kim, S. et al.
**摘要**: 通过流式细胞术和免疫沉淀(IP)结合MPZL2抗体，揭示了MPZL2在肿瘤微环境中调节PD-L1表达，影响T细胞功能及免疫治疗响应。
4. **文献名称**: *MPZL2 as a potential biomarker for colorectal cancer prognosis*
**作者**: Zhang, H. et al.
**摘要**: 使用MPZL2抗体进行组织芯片分析，发现MPZL2高表达与结直肠癌患者较差的总生存期相关，提示其作为预后标志物的潜力。
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**注意**：以上文献信息为示例性质，实际研究中请以具体数据库检索结果为准。
The MPZL2 antibody targets Myelin Protein Zero Like 2 (MPZL2), a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Structurally, MPZL2 contains an extracellular Ig-like domain, a single-pass transmembrane region, and a cytoplasmic tail, suggesting roles in cell-cell adhesion and signal transduction. Though less studied than its homolog MPZL1. MPZL2 is implicated in immune regulation and cancer biology. It is expressed in various tissues, including immune cells, epithelial cells, and certain tumors.
Research highlights MPZL2's interaction with SHP-1 phosphatase, modulating immune receptor signaling pathways like B-cell receptor (BCR) signaling. This interaction may influence immune tolerance and autoimmune responses. In oncology, MPZL2 is overexpressed in cancers such as hepatocellular carcinoma and breast cancer, where it potentially promotes tumor proliferation, migration, and immune evasion. Antibodies against MPZL2 are vital tools for detecting its expression via techniques like Western blot, immunohistochemistry, and flow cytometry, aiding studies on its functional mechanisms and therapeutic potential. Recent studies also explore MPZL2's role in viral infections, including hepatitis B, where it may interact with viral proteins to affect infection outcomes. Despite progress, MPZL2's precise biological functions and clinical relevance remain under investigation, necessitating further exploration of its signaling networks and disease associations.
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