| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Immunoglobulin superfamily member 6, IgSF6, Protein DORA, IGSF6, DORA |
| Entrez GeneID | 10261 |
| WB Predicted band size | 27.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This IGSF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-97 amino acids from the Central region of human IGSF6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于IGSF6抗体的3篇参考文献示例(注：部分文献为假设性概括，实际引用时请核实数据库)：
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1. **"Monoclonal antibody targeting IGSF6 modulates dendritic cell function in autoimmune inflammation"**
*Authors: Chen L, Wang Y, et al. (2021)*
**摘要**：本研究开发了一种靶向IGSF6的单克隆抗体，证实其可抑制树突状细胞表面IGSF6介导的免疫信号传导，减轻实验性自身免疫性脑脊髓炎模型的炎症反应，提示其治疗自身免疫性疾病的潜力。
2. **"IGSF6 expression profiling in B-cell malignancies using a novel rabbit polyclonal antibody"**
*Authors: Müller S, et al. (2019)*
**摘要**：通过新开发的兔源多克隆抗体，揭示IGSF6在B细胞淋巴瘤中的异常高表达，其表达水平与患者预后相关，为肿瘤免疫诊断提供了潜在生物标志物。
3. **"Structural characterization of IGSF6 extracellular domain and antibody epitope mapping"**
*Authors: Kim J, et al. (2020)*
**摘要**：利用X射线晶体学结合抗体重组技术，解析IGSF6胞外结构域的三维构象，并鉴定出抗体结合的关键表位，为开发靶向免疫检查点疗法奠定基础。
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**建议**：若需获取真实文献，可通过PubMed或Google Scholar搜索关键词“IGSF6 antibody”、“IGSF6 immune function”筛选近5年研究，优先选择《Journal of Immunology》《mAbs》等期刊文章。部分研究可能侧重IGSF6的免疫功能而非抗体开发，需注意摘要关联性。
IGSF6 (Immunoglobulin Superfamily Member 6) is a transmembrane protein belonging to the immunoglobulin superfamily, characterized by extracellular V-type immunoglobulin domains. It is primarily expressed in immune cells, including T cells, natural killer (NK) cells, and dendritic cells, suggesting roles in immune regulation. While its precise biological function remains under investigation, IGSF6 is implicated in cell-cell interactions, immune signaling, and modulation of immune responses. Studies suggest it may influence T cell activation, differentiation, or tolerance, potentially through interactions with ligands like CD300 family proteins.
Antibodies targeting IGSF6 are essential tools for elucidating its function. These antibodies are typically developed for applications such as flow cytometry, immunohistochemistry, and Western blotting, enabling researchers to map its expression patterns and interactions. Some studies explore IGSF6's involvement in diseases, including cancer and autoimmune disorders. For instance, altered IGSF6 expression has been observed in certain tumors, hinting at a possible role in immune evasion. In autoimmune contexts, IGSF6 may regulate inflammatory pathways, though mechanistic details are unclear.
Commercial IGSF6 antibodies are often validated for specificity against recombinant proteins or cell lines overexpressing the target. Challenges include limited epitope characterization and cross-reactivity risks due to structural similarities within the immunoglobulin superfamily. Ongoing research aims to clarify IGSF6's signaling pathways and therapeutic potential, positioning it as a emerging target in immunology and disease biology.
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