| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ceramide synthase 6, CerS6, LAG1 longevity assurance homolog 6, CERS6, LASS6 |
| Entrez GeneID | 253782 |
| WB Predicted band size | 44.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This LASS6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 335-361 amino acids from the C-terminal region of human LASS6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LASS6抗体的3篇示例文献(注：文献为示例性内容，实际文献需根据具体数据库检索)：
1. **《LASS6/CerS6调控胃癌细胞凋亡的机制研究》**
- 作者：李明等
- 摘要：本研究通过LASS6特异性抗体检测其在胃癌组织中的表达水平，发现LASS6通过调控神经酰胺合成抑制肿瘤细胞凋亡，并与患者不良预后相关。
2. **《CerS6在乳腺癌中的功能及其临床意义》**
- 作者：Chen X, et al.
- 摘要：利用LASS6抗体进行免疫组化分析，证实LASS6在乳腺癌中高表达，促进肿瘤侵袭转移，可能成为潜在治疗靶点。
3. **《LASS6抗体在结肠癌脂代谢研究中的应用》**
- 作者：Wang Y, et al.
- 摘要：通过Western blot和免疫荧光技术，验证LASS6抗体特异性，揭示LASS6通过影响脂筏结构调控结肠癌细胞耐药性。
**提示**：实际文献需通过PubMed、Google Scholar等平台以“LASS6 antibody”“CerS6”等关键词检索，并关注其在不同疾病模型或分子机制中的应用。
LASS6 (Longevity Assurance Homolog 6), also known as Ceramide Synthase 5 (CerS5), is a member of the ceramide synthase family involved in sphingolipid metabolism. It catalyzes the synthesis of C16-ceramide, a bioactive lipid regulating cellular processes like apoptosis, proliferation, and stress responses. Dysregulation of LASS6 has been implicated in cancer, metabolic disorders, and neurodegenerative diseases.
Antibodies targeting LASS6 are critical tools for studying its expression, localization, and function. Research shows LASS6 is overexpressed in certain cancers (e.g., breast, prostate) and may influence tumor progression by modulating ceramide levels. Conversely, reduced LASS6 activity correlates with chemoresistance and poor prognosis. Antibodies enable detection of LASS6 in tissues or cell lines via techniques like Western blot, immunohistochemistry, or immunofluorescence, aiding mechanistic studies.
Recent studies explore LASS6's role in lipid raft formation, mitochondrial function, and interactions with oncogenic pathways (e.g., EGFR, PI3K/AKT). Its dual role in promoting apoptosis or survival, depending on cellular context, makes it a nuanced therapeutic target. Commercial LASS6 antibodies are typically validated for specificity, often targeting epitopes in its N-terminal domain or catalytic regions.
Overall, LASS6 antibodies serve as essential reagents to unravel its pathophysiological roles and potential applications in diagnostics or targeted therapies.
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