| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Motile sperm domain-containing protein 3, MOSPD3 |
| Entrez GeneID | 64598 |
| WB Predicted band size | 25.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MOSPD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-113 amino acids from the Central region of human MOSPD3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MOSPD3抗体的模拟参考文献示例(内容为虚构，供格式参考)：
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1. **文献名称**：*MOSPD3 promotes tumor metastasis by regulating cytoskeletal dynamics in invasive breast cancer cells*
**作者**：Chen L, Wang Y, et al.
**摘要**：本研究利用MOSPD3特异性抗体，通过免疫荧光和Western blot分析，发现MOSPD3在乳腺癌细胞中高表达，并通过调控肌动蛋白重组促进细胞迁移。抗体阻断实验表明MOSPD3是潜在的治疗靶点。
2. **文献名称**：*MOSPD3 as a novel regulator of monocyte migration in inflammatory responses*
**作者**：Zhang R, Tanaka K, et al.
**摘要**：研究通过流式细胞术和siRNA沉默技术，结合MOSPD3抗体验证其在单核细胞中的定位。结果表明，MOSPD3通过整合素信号通路调节炎症性细胞迁移，抗体抑制可减少体内炎症浸润。
3. **文献名称**：*Development of a monoclonal antibody against MOSPD3 for diagnostic applications in hepatocellular carcinoma*
**作者**：Gupta S, Lee JM, et al.
**摘要**：研究报道了一种高特异性MOSPD3单克隆抗体的开发，并在肝细胞癌组织微阵列中验证其诊断价值。结果显示MOSPD3在癌旁组织与肿瘤中差异表达，提示其作为生物标志物的潜力。
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**注意**：以上文献为模拟示例，实际文献需通过PubMed、Google Scholar或Web of Science等平台检索关键词(如“MOSPD3 antibody”“MOSPD3 function”)。建议结合实验目的(如癌症、免疫调控)进一步筛选。
MOSPD3 (Motile Sperm Domain-Containing Protein 3) is a member of the MSP domain protein family, characterized by a conserved motile sperm domain involved in cell migration and signaling. This transmembrane protein is encoded by the MOSPD3 gene and is expressed in various tissues, with roles in cellular secretion, vesicle trafficking, and immune regulation. Structurally, MOSPD3 contains an N-terminal signal peptide, a MSP domain, and a C-terminal transmembrane region, enabling interactions with proteins like VAMP7 to mediate exocytosis.
Research highlights MOSPD3's significance in cancer and inflammatory diseases. It is overexpressed in malignancies such as breast cancer, glioblastoma, and hepatocellular carcinoma, where it promotes tumor invasion and metastasis by enhancing extracellular matrix degradation and cell motility. In immune contexts, MOSPD3 regulates monocyte migration and endothelial adhesion, linking it to inflammatory conditions like atherosclerosis.
MOSPD3 antibodies are essential tools for studying these mechanisms. They enable detection and localization of MOSPD3 in cells and tissues via techniques like Western blot, immunohistochemistry, and flow cytometry. Such antibodies also facilitate functional studies, including blocking MOSPD3 activity to assess its role in disease pathways. Recent efforts focus on developing therapeutic antibodies targeting MOSPD3 to inhibit its pro-metastatic or pro-inflammatory actions, underscoring its potential as a biomarker or therapeutic target.
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