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Rabbit Polyclonal ESYT1 Antibody

  • 中文名： ESYT1抗体
  • 别    名： Extended synaptotagmin-1, E-Syt1, Membrane-bound C2 domain-containing protein, ESYT1, FAM62A, KIAA0747, MBC2
货号: IPDX31707
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesExtended synaptotagmin-1, E-Syt1, Membrane-bound C2 domain-containing protein, ESYT1, FAM62A, KIAA0747, MBC2
Entrez GeneID23344
WB Predicted band size122.9kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis ESYT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1002-1031 amino acids from the C-terminal region of human ESYT1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于ESYT1抗体的3篇参考文献示例(部分为模拟虚构内容，实际文献需通过学术数据库确认)：

1. **文献名称**: "Characterization of ESYT1 Antibodies for Detecting Membrane Contact Sites in Mammalian Cells"

**作者**: Lee et al.

**摘要**: 本研究开发并验证了一种高特异性ESYT1多克隆抗体，用于检测哺乳动物细胞中ESYT1蛋白在内质网-质膜接触部位的定位。通过免疫印迹和免疫荧光实验证实其特异性，并揭示了ESYT1在钙信号调控中的作用。

2. **文献名称**: "ESYT1 Expression Profiling in Neurodegenerative Diseases Using a Novel Monoclonal Antibody"

**作者**: Rodriguez et al.

**摘要**: 文章报道了一种新型ESYT1单克隆抗体的开发，用于分析阿尔茨海默病模型小鼠脑组织中ESYT1的表达变化。抗体通过肽段免疫制备，验证了其在组织切片中的适用性，并发现ESYT1水平与突触功能障碍相关。

3. **文献名称**: "The Role of ESYT1 in Lipid Transfer: Insights from Antibody-mediated Functional Inhibition"

**作者**: Chen & Watanabe

**摘要**: 通过使用靶向ESYT1胞内结构域的功能阻断型抗体，本研究揭示了ESYT1在细胞间脂质运输中的关键作用。抗体应用实验表明，ESYT1缺失导致磷脂酰丝氨酸分布异常，提示其生理重要性。

**注**：以上文献为示例性质，实际研究需通过PubMed、Web of Science等平台检索关键词“ESYT1 antibody”获取。真实文献可能更侧重抗体在特定疾病模型或分子机制中的应用。

背景信息

The ESYT1 (Extended Synaptotagmin-1) antibody is a tool used to study the ESYT1 protein, a member of the extended synaptotagmin family involved in membrane contact site regulation. ESYT1 is a calcium-binding protein localized at endoplasmic reticulum-plasma membrane junctions, where it facilitates lipid transfer and membrane tethering. It contains a synaptotagmin-like lipid-binding domain and multiple C2 domains, enabling interactions with phospholipids and other membrane-associated proteins. Research on ESYT1 has highlighted its role in maintaining cellular homeostasis, including regulating calcium signaling, modulating membrane dynamics during vesicle trafficking, and influencing autophagy processes. Dysregulation of ESYT1 has been implicated in neurological disorders and cancer progression. The ESYT1 antibody is widely utilized in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect protein expression, subcellular localization, and molecular interactions. Its specificity and reliability make it critical for exploring ESYT1’s functional mechanisms in membrane remodeling and inter-organelle communication. Recent studies also investigate its potential as a biomarker or therapeutic target, emphasizing its growing importance in cell biology and disease research.

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