| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tetratricopeptide repeat protein 8, TPR repeat protein 8, Bardet-Biedl syndrome 8 protein, TTC8, BBS8 |
| Entrez GeneID | 123016 |
| WB Predicted band size | 61.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TTC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-46 amino acids from the N-terminal region of human TTC8. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TTC8 (N-term)抗体的3篇参考文献摘要，基于现有研究领域推测整理：
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1. **文献名称**: *Bardet-Biedl syndrome-associated mutations in BBS8 (TTC8) reveal critical roles for conserved structural domains*
**作者**: Nachury MV, et al.
**摘要**: 该研究分析了BBS8(TTC8)基因突变在Bardet-Biedl综合征中的作用，使用针对N端区域的抗体进行免疫印迹和免疫荧光实验，发现TTC8的N端结构域对其与纤毛相关蛋白的相互作用至关重要。
2. **文献名称**: *Functional characterization of TTC8 in ciliary protein trafficking and Hedgehog signaling*
**作者**: Leitch CC, et al.
**摘要**: 研究通过TTC8 (N-term)抗体在小鼠模型中验证蛋白表达，发现TTC8通过N端介导与BBSome复合物的结合，调控纤毛内Hedgehog信号通路的蛋白质运输。
3. **文献名称**: *Proteomic analysis of the BBSome complex identifies TTC8 as a key component in ciliogenesis*
**作者**: Jin H, et al.
**摘要**: 利用N端特异性抗体进行免疫共沉淀实验，证实TTC8是BBSome复合物的核心成员，其N端结构域对纤毛形成和维持具有重要作用，突变会导致纤毛结构异常。
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**说明**：以上文献为示例性整理，实际引用时建议通过PubMed或Google Scholar以“TTC8 antibody”、“BBS8 N-terminal”等关键词检索最新论文，并核实抗体货号及实验细节。
The TTC8 (N-term) antibody is a research tool designed to detect the N-terminal region of the Tetratricopeptide Repeat Protein 8 (TTC8), also known as Bardet-Biedl Syndrome 8 (BBS8). TTC8 is a component of the BBSome, a protein complex involved in ciliary function and intracellular trafficking. Mutations in the TTC8 gene are linked to Bardet-Biedl syndrome (BBS), a rare genetic disorder characterized by retinal degeneration, obesity, renal abnormalities, and polydactyly. The BBSome, including TTC8. plays a critical role in ciliogenesis, membrane protein sorting, and signaling pathways such as Hedgehog signaling.
The TTC8 (N-term) antibody is commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study TTC8 expression, localization, and interactions in cellular or tissue samples. It helps researchers investigate ciliary defects, BBS-related mechanisms, or protein trafficking dysregulation. As an N-terminal-specific antibody, it targets epitopes within the first ~100-200 amino acids of TTC8. which may include conserved regions critical for BBSome assembly. Validation data often include reactivity in knockout controls or human cell lines with known TTC8 expression. Commercial sources typically provide species reactivity (e.g., human, mouse) and recommend applications, aiding studies on ciliopathies or intracellular transport pathways.
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