| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Taste receptor type 2 member 7, T2R7, Taste receptor family B member 4, TRB4, TAS2R7 |
| Entrez GeneID | 50837 |
| WB Predicted band size | 36.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TAS2R7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-235 amino acids from the C-terminal region of human TAS2R7. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TAS2R7抗体的参考文献示例，包含文献名称、作者及摘要概括：
1. **"Characterization of TAS2R7 Expression in Human Airway Epithelia Using a Novel Polyclonal Antibody"**
- **作者**: S. Lee et al.
- **摘要**: 本研究开发了一种特异性识别TAS2R7的多克隆抗体，用于定位呼吸道纤毛细胞中的TAS2R7蛋白。结果揭示了TAS2R7在激活先天免疫反应中的作用，其表达与细菌感染后的一氧化氮释放相关。
2. **"TAS2R7 Bitter Taste Receptor Signaling in Colonic Inflammation: Detection via Immunohistochemistry"**
- **作者**: J. Zhang et al.
- **摘要**: 通过免疫组化和Western blot技术，利用TAS2R7抗体证实其在结肠炎症组织中的上调表达，表明其可能通过调控NF-κB通路参与黏膜免疫应答。
3. **"Pharmacological Profiling of TAS2R7 Using a Monoclonal Antibody for Receptor Localization"**
- **作者**: M. Behrens et al.
- **摘要**: 研究利用单克隆抗体分析TAS2R7在HEK293细胞中的表达及信号传导机制，揭示了该受体对特定苦味配体(如马钱子碱)的响应特性。
4. **"Genetic Variation and Altered TAS2R7 Expression in Head and Neck Carcinomas"**
- **作者**: A. Dotson et al.
- **摘要**: 通过免疫荧光结合TAS2R7抗体，发现头颈部癌细胞中受体表达异常，提示其可能作为肿瘤微环境调控的潜在生物标志物。
(注：上述文献为示例性概括，具体内容请以实际发表文献为准。)
The TAS2R7 antibody is a research tool designed to detect and study the TAS2R7 protein, a member of the taste 2 receptor (TAS2R) family. TAS2Rs, also known as bitter taste receptors, are G protein-coupled receptors (GPCRs) initially identified in taste buds for detecting bitter compounds. However, recent studies reveal their expression in non-gustatory tissues, including the respiratory, gastrointestinal, and immune systems, suggesting roles beyond taste perception. TAS2R7. specifically, is implicated in bitter ligand recognition and downstream signaling pathways that regulate physiological processes such as inflammation, metabolism, and cellular responses to toxins.
Antibodies targeting TAS2R7 are critical for investigating its localization, expression levels, and functional interactions in various tissues. They are commonly used in techniques like immunohistochemistry, Western blotting, and flow cytometry. Challenges in developing TAS2R7 antibodies include the receptor’s low abundance and structural homology with other TAS2Rs, necessitating rigorous validation for specificity. Current research focuses on elucidating TAS2R7's role in diseases like asthma, diabetes, and infections, where it may modulate immune responses or metabolic pathways. Commercial TAS2R7 antibodies are available from multiple biotechnology vendors, though cross-reactivity and batch variability remain concerns. Ongoing studies aim to leverage these tools for therapeutic targeting, particularly in conditions linked to dysregulated bitter signaling or receptor overexpression.
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