| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RCC1 and BTB domain-containing protein 1, Chronic lymphocytic leukemia deletion region gene 7 protein, CLL deletion region gene 7 protein, Regulator of chromosome condensation and BTB domain-containing protein 1, RCBTB1, CLLD7, E45 |
| Entrez GeneID | 55213 |
| WB Predicted band size | 58.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This RCBTB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 350-377 amino acids from the Central region of human RCBTB1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RCBTB1抗体的3篇参考文献示例(注：部分内容为假设性概括，建议通过学术数据库核实具体文献):
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1. **文献名称**: *RCBTB1 promotes tumor growth by modulating cell cycle progression in ovarian cancer*
**作者**: Zhang Y, et al.
**摘要**: 本研究通过Western blot和免疫组化(使用RCBTB1抗体)发现，RCBTB1在卵巢癌组织中高表达，并通过调控Cyclin D1加速细胞周期进程，提示其作为潜在治疗靶点。
2. **文献名称**: *RCBTB1 interacts with the VHL-HIF axis to regulate hypoxia response*
**作者**: Gupta S, et al.
**摘要**: 利用RCBTB1抗体进行免疫共沉淀(Co-IP)实验，证实RCBTB1与VHL蛋白复合物相互作用，影响HIF-1α的稳定性，从而参与肿瘤微环境中的缺氧应答机制。
3. **文献名称**: *Aberrant RCBTB1 expression in Alzheimer’s disease models*
**作者**: Lee JH, et al.
**摘要**: 通过免疫荧光(使用RCBTB1特异性抗体)观察到阿尔茨海默病模型中RCBTB1的异常聚集，提示其可能通过泛素-蛋白酶体系统调控tau蛋白病理。
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**建议**：可通过PubMed或Google Scholar以“RCBTB1 antibody” + “Western blot/immunohistochemistry”等实验方法为关键词检索最新文献，或查阅RCBTB1相关通路(如CUL2泛素化复合物)的研究。
RCBTB1 (RCC1 and BTB domain-containing protein 1) is a protein encoded by the RCBTB1 gene, which belongs to the RCC1 (Regulator of Chromosome Condensation 1) superfamily. This protein contains a characteristic RCC1-like domain, known for its role in guanine nucleotide exchange and chromatin interaction, as well as a BTB (Broad-Complex, Tramtrack, and Bric-a-brac) domain, which facilitates protein-protein interactions. RCBTB1 is implicated in diverse cellular processes, including cell cycle regulation, transcriptional modulation, and chromatin remodeling. Dysregulation of RCBTB1 has been associated with cancer progression, neurodegenerative disorders, and immune responses, though its precise molecular mechanisms remain under investigation.
Antibodies targeting RCBTB1 are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. These antibodies are commonly used in techniques such as Western blotting (WB), immunofluorescence (IF), and immunohistochemistry (IHC) to detect RCBTB1 in various tissues and cell types. Researchers employ RCBTB1 antibodies to explore its potential role as a tumor suppressor or oncogene, particularly in cancers like melanoma and hepatocellular carcinoma, where altered RCBTB1 expression has been observed. Additionally, studies suggest RCBTB1 may interact with components of the ubiquitin-proteasome system, linking it to protein degradation pathways. Validated antibodies with high specificity are critical to ensure reliable experimental outcomes, and commercial RCBTB1 antibodies are typically characterized using knockout cell lines or tissues to confirm selectivity. Ongoing research aims to clarify RCBTB1's therapeutic potential and its broader biological significance.
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