| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Kelch-like protein 38, KLHL38, C8orfK36 |
| Entrez GeneID | 340359 |
| WB Predicted band size | 65.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This KLHL38 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-104 amino acids from the N-terminal region of human KLHL38. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于KLHL38 (N-term)抗体的假设性参考文献示例(注：实际文献可能需要通过学术数据库验证)：
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1. **文献名称**：*KLHL38 regulates skeletal muscle development via ubiquitin-mediated proteolysis*
**作者**：Chen L, et al.
**摘要**：本研究通过KLHL38 (N-term)抗体进行Western blot和免疫组化，发现KLHL38在骨骼肌分化过程中特异性表达，并通过泛素化通路调控肌细胞增殖相关蛋白的降解。
2. **文献名称**：*Identification of KLHL38 as a novel interactor of Cullin3 ubiquitin ligase complexes*
**作者**：Wang Y, et al.
**摘要**：利用KLHL38 (N-term)抗体进行免疫共沉淀实验，证实KLHL38通过N端结构域与Cullin3结合，参与细胞周期调控蛋白的泛素化修饰，影响肿瘤细胞增殖。
3. **文献名称**：*Tissue-specific expression profiling of KLHL family members in mammalian organs*
**作者**：Kimura T, et al.
**摘要**：通过KLHL38 (N-term)抗体的免疫荧光分析，揭示了KLHL38在小鼠心脏和肾脏组织中的高表达模式，提示其可能在器官发育中发挥独特作用。
4. **文献名称**：*KLHL38 antibody validation for functional studies in zebrafish models*
**作者**：Gonzalez R, et al.
**摘要**：本研究验证了KLHL38 (N-term)抗体在斑马鱼胚胎中的特异性，证明其可用于检测KLHL38在早期发育阶段的动态表达，并关联其与胚胎肌肉形成的联系。
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**备注**：以上文献为示例性质，实际引用需通过PubMed、Google Scholar等平台检索具体研究。部分商业抗体公司(如Abcam、Sigma-Aldrich)的产品说明书也可能提供相关参考文献。
The KLHL38 (N-term) antibody is designed to target the N-terminal region of the Kelch-like protein 38 (KLHL38), a member of the Kelch-like (KLHL) family. KLHL proteins typically function as substrate adaptors for Cullin-RING E3 ubiquitin ligase complexes, facilitating the ubiquitination and subsequent degradation of specific substrates. KLHL38. though less characterized compared to other KLHL members, is implicated in cellular processes such as protein homeostasis, cytoskeletal organization, and possibly tissue-specific signaling. Its N-terminal domain, containing a BTB/POZ motif, mediates interactions with Cullin-3. a critical component of the ubiquitin ligase complex.
This antibody is commonly used in research to detect endogenous KLHL38 protein levels via techniques like Western blotting, immunohistochemistry, or immunofluorescence. Its specificity for the N-terminal region ensures recognition of full-length KLHL38. avoiding cross-reactivity with degradation products or homologous proteins. Validation often includes knockout/knockdown controls to confirm signal absence in KLHL38-deficient samples.
Research applications focus on elucidating KLHL38's physiological roles, particularly in muscle development, spermatogenesis, or disease contexts like cancer, where ubiquitination pathways are dysregulated. The antibody also aids in studying KLHL38-interacting partners and its regulatory mechanisms. Host species (e.g., rabbit, mouse) and clonality (monoclonal/polyclonal) vary by commercial source, requiring optimization for specific experimental conditions.
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